Reactome | OPTN binds CASP8

Schema > Reaction > Entries

category	binding
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:10102717] Weiser, Joel, 2026-03-16
dbId	10216707
displayName	OPTN binds CASP8
eventOf	[Pathway:R-RNO-5357905] Regulation of TNFR1 signaling - Rattus norvegicus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-9823816] OPTN binds CASP8 - Homo sapiens
input	[EntityWithAccessionedSequence:R-RNO-57031] Casp8 [cytosol] [EntityWithAccessionedSequence:R-RNO-9687907] OPTN [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	OPTN binds CASP8
output	[Complex:R-RNO-9823815] OPTN:CASP8 [cytosol]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48895] Rattus norvegicus
stId	R-RNO-9823816
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

(hasEvent)	[Pathway:R-RNO-5357905] Regulation of TNFR1 signaling
(inferredTo)	[Reaction:R-HSA-9823816] OPTN binds CASP8