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Casp8 [cytosol]
Stable Identifier
R-RNO-57031
Type
Protein [EntityWithAccessionedSequence]
Species
Rattus norvegicus
Compartment
cytosol
Synonyms
CASP8(1-479), Q9JHX4
Locations in the PathwayBrowser
Expand all
Immune System (Rattus norvegicus)
Innate Immune System (Rattus norvegicus)
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways (Rattus norvegicus)
NOD1/2 Signaling Pathway (Rattus norvegicus)
NOD1 induced apoptosis is mediated by RIP2 and CARD8 (Rattus norvegicus)
Long prodomain caspases [cytosol] (Rattus norvegicus)
Casp8 [cytosol] (Rattus norvegicus)
NOD1:iE-DAP:Long prodomain caspases [cytosol] (Rattus norvegicus)
Long prodomain caspases [cytosol] (Rattus norvegicus)
Casp8 [cytosol] (Rattus norvegicus)
Toll-like Receptor Cascades (Rattus norvegicus)
Toll Like Receptor 4 (TLR4) Cascade (Rattus norvegicus)
MyD88-independent TLR4 cascade (Rattus norvegicus)
TRIF (TICAM1)-mediated TLR4 signaling (Rattus norvegicus)
TRIF-mediated programmed cell death (Rattus norvegicus)
Caspase-8 processing within TLR4 complex (Rattus norvegicus)
Casp8 [cytosol] (Rattus norvegicus)
activated TLR4:TRIF:RIP1:FADD:pro-caspase-8 [endosome membrane] (Rattus norvegicus)
Casp8 [cytosol] (Rattus norvegicus)
TLR4-induced ripoptosome assembly (Rattus norvegicus)
Casp8 [cytosol] (Rattus norvegicus)
activated TLR4:TRIF:RIP1:FADD:pro-caspase-8 [endosome membrane] (Rattus norvegicus)
Casp8 [cytosol] (Rattus norvegicus)
Programmed Cell Death (Rattus norvegicus)
Apoptosis (Rattus norvegicus)
Caspase activation via extrinsic apoptotic signalling pathway (Rattus norvegicus)
Caspase activation via Death Receptors in the presence of ligand (Rattus norvegicus)
Caspase-8 processing within TLR4 complex (Rattus norvegicus)
Casp8 [cytosol] (Rattus norvegicus)
activated TLR4:TRIF:RIP1:FADD:pro-caspase-8 [endosome membrane] (Rattus norvegicus)
Casp8 [cytosol] (Rattus norvegicus)
Dimerization of procaspase-8 (Rattus norvegicus)
FAS-mediated dimerization of procaspase-8 (Rattus norvegicus)
Casp8 [cytosol] (Rattus norvegicus)
FASL:FAS receptor trimer:FADD:procaspase-8-dimer [plasma membrane] (Rattus norvegicus)
procaspase-8 dimer [cytosol] (Rattus norvegicus)
Casp8 [cytosol] (Rattus norvegicus)
FASL:FAS trimer:FADD:CASP8(1-479) [plasma membrane] (Rattus norvegicus)
Casp8 [cytosol] (Rattus norvegicus)
TNF-mediated dimerization of procaspase-8 (Rattus norvegicus)
Casp8 [cytosol] (Rattus norvegicus)
TRADD:TRAF2:RIP1:FADD:CASP8(1-479) [cytosol] (Rattus norvegicus)
Casp8 [cytosol] (Rattus norvegicus)
TRAF2:TRADD:RIP1:FADD:2xCASP8(1-479) [cytosol] (Rattus norvegicus)
procaspase-8 dimer [cytosol] (Rattus norvegicus)
Casp8 [cytosol] (Rattus norvegicus)
TRAIL-mediated dimerization of procaspase-8 (Rattus norvegicus)
Casp8 [cytosol] (Rattus norvegicus)
TNFSF10:TNFRSF10A,B:FADD:2xCASP8(1-479) [plasma membrane] (Rattus norvegicus)
procaspase-8 dimer [cytosol] (Rattus norvegicus)
Casp8 [cytosol] (Rattus norvegicus)
TNFSF10:TNFRSF10A,B:FADD:CASP8(1-479) [plasma membrane] (Rattus norvegicus)
Casp8 [cytosol] (Rattus norvegicus)
Regulation by c-FLIP (Rattus norvegicus)
Caspase-8 and FLIP(L) processing at DISC (Rattus norvegicus)
DISC:procaspase-8:FLIP(L) [plasma membrane] (Rattus norvegicus)
DISC:procaspase-8 [plasma membrane] (Rattus norvegicus)
Casp8 [cytosol] (Rattus norvegicus)
FLIP(L) and procaspase-8 form heterodimer in FasL/CD95 signaling (Rattus norvegicus)
FASL:FAS Receptor Trimer:FADD:pro-Caspase-8:FLIP(L) [plasma membrane] (Rattus norvegicus)
Casp8 [cytosol] (Rattus norvegicus)
FASL:FAS trimer:FADD:CASP8(1-479) [plasma membrane] (Rattus norvegicus)
Casp8 [cytosol] (Rattus norvegicus)
FLIP(L) and procaspase-8 form heterodimer in TNF signaling (Rattus norvegicus)
Casp8 [cytosol] (Rattus norvegicus)
TRADD:TRAF2:RIP1:FADD:procaspase-8:FLIP(L) [cytosol] (Rattus norvegicus)
Casp8 [cytosol] (Rattus norvegicus)
FLIP(L) and procaspase-8 form heterodimer in TRAIL signaling (Rattus norvegicus)
TNFSF10:TNFRSF10A,B:FADD:CASP8(1-479) [plasma membrane] (Rattus norvegicus)
Casp8 [cytosol] (Rattus norvegicus)
TNFSF10:TNFRSF10A,B:FADD:CASP8(1-479):CFLAR [plasma membrane] (Rattus norvegicus)
Casp8 [cytosol] (Rattus norvegicus)
Regulated Necrosis (Rattus norvegicus)
RIPK1-mediated regulated necrosis (Rattus norvegicus)
Regulation of necroptotic cell death (Rattus norvegicus)
CASP8 activity is inhibited (Rattus norvegicus)
FLIP(L) and procaspase-8 form heterodimer (Rattus norvegicus)
DISC:procaspase-8 [plasma membrane] (Rattus norvegicus)
Casp8 [cytosol] (Rattus norvegicus)
DISC:procaspase-8:FLIP(L) [plasma membrane] (Rattus norvegicus)
DISC:procaspase-8 [plasma membrane] (Rattus norvegicus)
Casp8 [cytosol] (Rattus norvegicus)
FLIP(S) and procaspase-8 form heterodimer (Rattus norvegicus)
DISC:procaspase-8 [plasma membrane] (Rattus norvegicus)
Casp8 [cytosol] (Rattus norvegicus)
DISC:procaspase-8:FLIP(S) [plasma membrane] (Rattus norvegicus)
DISC:procaspase-8 [plasma membrane] (Rattus norvegicus)
Casp8 [cytosol] (Rattus norvegicus)
Signal Transduction (Rattus norvegicus)
Death Receptor Signaling (Rattus norvegicus)
FasL/ CD95L signaling (Rattus norvegicus)
FASL:FAS Receptor Trimer:FADD complex binds pro-Caspase-8 (Rattus norvegicus)
Casp8 [cytosol] (Rattus norvegicus)
FASL:FAS trimer:FADD:CASP8(1-479) [plasma membrane] (Rattus norvegicus)
Casp8 [cytosol] (Rattus norvegicus)
TNF signaling (Rattus norvegicus)
Regulation of TNFR1 signaling (Rattus norvegicus)
Caspase-8 and FLIP(L) processing at TNFR signaling complex (Rattus norvegicus)
TRADD:TRAF2:RIP1:FADD:procaspase-8:FLIP(L) [cytosol] (Rattus norvegicus)
Casp8 [cytosol] (Rattus norvegicus)
FLIP(L) and procaspase-8 form heterodimer in TNF signaling (Rattus norvegicus)
Casp8 [cytosol] (Rattus norvegicus)
TRADD:TRAF2:RIP1:FADD:procaspase-8:FLIP(L) [cytosol] (Rattus norvegicus)
Casp8 [cytosol] (Rattus norvegicus)
OPTN binds CASP8 (Rattus norvegicus)
Casp8 [cytosol] (Rattus norvegicus)
OPTN:CASP8 [cytosol] (Rattus norvegicus)
Casp8 [cytosol] (Rattus norvegicus)
TRAIL signaling (Rattus norvegicus)
TRAIL:TRAIL Receptor Trimer:FADD complex binds procaspase-8 (Rattus norvegicus)
Casp8 [cytosol] (Rattus norvegicus)
TNFSF10:TNFRSF10A,B:FADD:CASP8(1-479) [plasma membrane] (Rattus norvegicus)
Casp8 [cytosol] (Rattus norvegicus)
External Reference Information
External Reference
UniProt:Q9JHX4
Gene Names
Casp8
Reference Genes
BioGPS Gene:64044 Casp8
ENSEMBL:ENSRNOG00000012331
ENSEMBL:ENSRNOG00000012331.7 Casp8
ENSEMBL:ENSRNOG00055023227
ENSEMBL:ENSRNOG00060017095
ENSEMBL:ENSRNOG00065029007
KEGG Gene (Rattus norvegicus):64044 Casp8
Monarch:64044 Casp8
NCBI Gene:64044 Casp8
UCSC:Q9JHX4 Casp8
Reference Transcript
RefSeq:NM_022277.1 Casp8
RefSeq:XM_006245015.3 Casp8
Other Identifiers
10923595
1369262_at
1380297_at
17859543
5755091
5762731
5836514
5842903
5939525
6222573
6374698
64044
6410446
6502559
6536256
6550784
A_44_P298210
GE1112482
GE1182044
GO:0002376
GO:0003824
GO:0004197
GO:0005515
GO:0005634
GO:0005654
GO:0005737
GO:0005829
GO:0005886
GO:0006508
GO:0006915
GO:0008233
GO:0008234
GO:0012501
GO:0016787
GO:0023052
GO:0030027
GO:0030154
GO:0030163
GO:0030335
GO:0031264
GO:0031265
GO:0031625
GO:0032731
GO:0032991
GO:0034612
GO:0035877
GO:0036462
GO:0042802
GO:0042981
GO:0043123
GO:0043124
GO:0043226
GO:0045651
GO:0045862
GO:0048856
GO:0048870
GO:0051603
GO:0051604
GO:0060546
GO:0071260
GO:0097110
GO:0097153
GO:0097190
GO:0097191
GO:0097194
GO:0097199
GO:0097342
GO:0140096
ILMN_1371431
PH_rn_0008354
Participates
as an input of
OPTN binds CASP8 (Rattus norvegicus)
FLIP(L) and procaspase-8 form heterodimer in TNF signaling (Rattus norvegicus)
FAS-mediated dimerization of procaspase-8 (Rattus norvegicus)
FASL:FAS Receptor Trimer:FADD complex binds pro-Caspase-8 (Rattus norvegicus)
TRAIL-mediated dimerization of procaspase-8 (Rattus norvegicus)
TRAIL:TRAIL Receptor Trimer:FADD complex binds procaspase-8 (Rattus norvegicus)
TNF-mediated dimerization of procaspase-8 (Rattus norvegicus)
TLR4-induced ripoptosome assembly (Rattus norvegicus)
as a component of
TNFSF10:TNFRSF10A,B:FADD:CASP8(1-479):CFLAR [plasma membrane] (Rattus norvegicus)
FASL:FAS Receptor Trimer:FADD:pro-Caspase-8:FLIP(L) [plasma membrane] (Rattus norvegicus)
TRADD:TRAF2:RIP1:FADD:procaspase-8:FLIP(L) [cytosol] (Rattus norvegicus)
FASL:FAS trimer:FADD:CASP8(1-479) [plasma membrane] (Rattus norvegicus)
TNFSF10:TNFRSF10A,B:FADD:CASP8(1-479) [plasma membrane] (Rattus norvegicus)
OPTN:CASP8 [cytosol] (Rattus norvegicus)
TRADD:TRAF2:RIP1:FADD:CASP8(1-479) [cytosol] (Rattus norvegicus)
DISC:procaspase-8 [plasma membrane] (Rattus norvegicus)
activated TLR4:TRIF:RIP1:FADD:pro-caspase-8 [endosome membrane] (Rattus norvegicus)
procaspase-8 dimer [cytosol] (Rattus norvegicus)
as a member of
Long prodomain caspases [cytosol] (Rattus norvegicus)
Other forms of this molecule
Casp8 [cytosol]
Casp8 [mitochondrial outer membrane]
Casp8 [mitochondrial outer membrane]
Casp8 [cytosol]
Casp8 [cytosol]
Inferred From
CASP8(1-479) [cytosol]
(Homo sapiens)
Cross References
RefSeq
XP_006245077.1
,
NP_071613.1
Ensembl
ENSRNOG00000012331
,
ENSRNOP00000016613
,
ENSRNOT00000016613
PRO
Q9JHX4
RGD
620945
Interactors (1)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q8R2E7
1
Fadd [cytosol]
(R-RNO-54639)
0.499
2
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