Reactome | FAS-mediated dimerization of procaspase-8

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FAS-mediated dimerization of procaspase-8 Show undefined attributes

category	binding
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol
created	[InstanceEdit:10102717] Weiser, Joel, 2026-03-16
dbId	10107935
displayName	FAS-mediated dimerization of procaspase-8
eventOf	[Pathway:R-RNO-69416] Dimerization of procaspase-8 - Rattus norvegicus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-73945] FAS-mediated dimerization of procaspase-8 - Homo sapiens
input	[EntityWithAccessionedSequence:R-RNO-57031] Casp8 [cytosol] [Complex:R-RNO-75114] FASL:FAS trimer:FADD:CASP8(1-479) [plasma membrane]
isInDisease	false
isInferred	true
maxDepth	1
name	FAS-mediated dimerization of procaspase-8
output	[Complex:R-RNO-2671811] FASL:FAS receptor trimer:FADD:procaspase-8-dimer [plasma membrane]
precedingEvent	[Reaction:R-RNO-83586] FASL:FAS Receptor Trimer:FADD complex binds pro-Caspase-8 - Rattus norvegicus
regulatedBy	[NegativeRegulation:10107936] Negative regulation by 'FLIP(S) [cytosol]'
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48895] Rattus norvegicus
stId	R-RNO-73945
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-RNO-69416] Dimerization of procaspase-8
(inferredTo)	[Reaction:R-HSA-73945] FAS-mediated dimerization of procaspase-8

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