Reactome | Calcineurin binds and dephosphorylates NFAT1 in response to WNT/Ca2+ signaling

Schema > Reaction > Entries

Calcineurin binds and dephosphorylates NFAT1 in response to WNT/Ca2+ signaling Show undefined attributes

catalystActivity	[CatalystActivity:10167969] calmodulin-dependent protein phosphatase activity of Calcineurin:Calmodulin (CaN:CaM) [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:10102717] Weiser, Joel, 2026-03-16
dbId	10173293
displayName	Calcineurin binds and dephosphorylates NFAT1 in response to WNT/Ca2+ signaling
eventOf	[Pathway:R-RNO-4086398] Ca2+ pathway - Rattus norvegicus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[BlackBoxEvent:R-RNO-4551465] Translocation of NFATC1:CaN:CaM to nucleus - Rattus norvegicus
inferredFrom	[Reaction:R-HSA-4551451] Calcineurin binds and dephosphorylates NFAT1 in response to WNT/Ca2+ signaling - Homo sapiens
input	[Complex:R-RNO-2025947] Calcineurin:Calmodulin (CaN:CaM) [cytosol] [SimpleEntity:R-ALL-29356] H2O [cytosol] [EntityWithAccessionedSequence:R-RNO-2025953] phospho-Nfatc1 [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	Calcineurin binds and dephosphorylates NFAT1 in response to WNT/Ca2+ signaling
output	[Complex:R-RNO-4551448] NFATC1:CaN:CaM [cytosol] 11 × [SimpleEntity:R-ALL-29372] Pi [cytosol]
precedingEvent	[Reaction:R-RNO-2730872] Activation of Calcineurin - Rattus norvegicus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48895] Rattus norvegicus
stId	R-RNO-4551451
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-RNO-4086398] Ca2+ pathway
(precedingEvent)	[BlackBoxEvent:R-RNO-4551465] Translocation of NFATC1:CaN:CaM to nucleus
(inferredTo)	[Reaction:R-HSA-4551451] Calcineurin binds and dephosphorylates NFAT1 in response to WNT/Ca2+ signaling

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