Reactome | NLK phosphorylates TCF/LEF

Schema > Reaction > Entries

NLK phosphorylates TCF/LEF Show undefined attributes

catalystActivity	[CatalystActivity:10173164] protein serine/threonine kinase activity of pT298-NLK dimer [nucleoplasm]
category	transition
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:10102717] Weiser, Joel, 2026-03-16
dbId	10173166
displayName	NLK phosphorylates TCF/LEF
eventOf	[Pathway:R-RNO-4086398] Ca2+ pathway - Rattus norvegicus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-4411383] NLK phosphorylates TCF/LEF - Homo sapiens
input	2 × [SimpleEntity:R-ALL-29358] ATP [nucleoplasm] [Complex:R-RNO-4411397] TCF/LEF:CTNNB1 [nucleoplasm]
isInDisease	false
isInferred	true
maxDepth	1
name	NLK phosphorylates TCF/LEF
output	2 × [SimpleEntity:R-ALL-113582] ADP [nucleoplasm] [Complex:R-RNO-4411380] p-TCF/LEF:CTNNB1 [nucleoplasm]
precedingEvent	[BlackBoxEvent:R-RNO-4411373] NLK translocates to nucleus - Rattus norvegicus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48895] Rattus norvegicus
stId	R-RNO-4411383
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-RNO-4086398] Ca2+ pathway
(inferredTo)	[Reaction:R-HSA-4411383] NLK phosphorylates TCF/LEF

Cite Us!