Reactome | WNT:FZD complex promotes G-protein nucleotide exchange

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WNT:FZD complex promotes G-protein nucleotide exchange Show undefined attributes

catalystActivity	[CatalystActivity:10172506] guanyl-nucleotide exchange factor activity of WNT5A/11:FZD:G-protein (alpha o/t2) inactive [plasma membrane]
category	transition
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol [Compartment:984] extracellular region
created	[InstanceEdit:10102717] Weiser, Joel, 2026-03-16
dbId	10172508
displayName	WNT:FZD complex promotes G-protein nucleotide exchange
eventOf	[Pathway:R-RNO-4086398] Ca2+ pathway - Rattus norvegicus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-3965444] WNT:FZD complex promotes G-protein nucleotide exchange - Homo sapiens
input	[SimpleEntity:R-ALL-29438] GTP [cytosol] [Complex:R-RNO-3965393] WNT5A/11:FZD:G-protein (alpha o/t2) inactive [plasma membrane]
isInDisease	false
isInferred	true
maxDepth	1
name	WNT:FZD complex promotes G-protein nucleotide exchange
output	[SimpleEntity:R-ALL-29420] GDP [cytosol] [Complex:R-RNO-3965394] WNT5A/11:FZD:G-protein (alpha o/t2) active [plasma membrane]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48895] Rattus norvegicus
stId	R-RNO-3965444
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-RNO-4086398] Ca2+ pathway
(inferredTo)	[Reaction:R-HSA-3965444] WNT:FZD complex promotes G-protein nucleotide exchange

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