Reactome | Androgen biosynthesis

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Androgen biosynthesis Show undefined attributes

created	[InstanceEdit:10102717] Weiser, Joel, 2026-03-16
dbId	10223171
displayName	Androgen biosynthesis
eventOf	[Pathway:R-RNO-196071] Metabolism of steroid hormones - Rattus norvegicus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
goBiologicalProcess	[GO_BiologicalProcess:21391] androgen biosynthetic process
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-RNO-193068] CYP17A1 17-hydroxylates PREG - Rattus norvegicus [Reaction:R-RNO-193070] CYP17A1 cleaves 17aHPREG to DHA - Rattus norvegicus [Reaction:R-RNO-193073] HSD2B1 dimer, HSD3B2 dimer isomerise DHA to ANDST - Rattus norvegicus [Reaction:R-RNO-193072] CYP17A1 17-hydroxylates P4 to 17aHPROG - Rattus norvegicus [Reaction:R-RNO-193099] CYP17A1 cleaves 17aHPROG to ANDST - Rattus norvegicus [Reaction:R-RNO-193064] HSD17B3-like proteins reducde ANDST to TEST - Rattus norvegicus [Reaction:R-RNO-469659] SRD5A1 dehydrogenates TEST to DHTEST - Rattus norvegicus [Reaction:R-RNO-9705713] SRD5A2 dehydrogenates TEST to DHTEST - Rattus norvegicus [Reaction:R-RNO-9705794] SRD5A2 binds SRD5A2 inhibitors - Rattus norvegicus [Reaction:R-RNO-9705714] SRD5A3 dehydrogenates TEST to DHTEST - Rattus norvegicus
inferredFrom	[Pathway:R-HSA-193048] Androgen biosynthesis - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	2
name	Androgen biosynthesis
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:48895] Rattus norvegicus
stId	R-RNO-193048
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-RNO-196071] Metabolism of steroid hormones
(inferredTo)	[Pathway:R-HSA-193048] Androgen biosynthesis

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