Reactome | HSD2B1 dimer, HSD3B2 dimer isomerise DHA to ANDST

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HSD2B1 dimer, HSD3B2 dimer isomerise DHA to ANDST Show undefined attributes

catalystActivity	[CatalystActivity:10122238] steroid Delta-isomerase activity of HSD3B1 dimer, HSD3B2 dimer [endoplasmic reticulum membrane]
category	transition
compartment	[Compartment:70101] cytosol [Compartment:12045] endoplasmic reticulum membrane
created	[InstanceEdit:10102717] Weiser, Joel, 2026-03-16
dbId	10122334
displayName	HSD2B1 dimer, HSD3B2 dimer isomerise DHA to ANDST
eventOf	[Pathway:R-RNO-193048] Androgen biosynthesis - Rattus norvegicus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-RNO-193064] HSD17B3-like proteins reducde ANDST to TEST - Rattus norvegicus [Reaction:R-RNO-193060] CYP19A1 hydroxylates ANDST to E1 - Rattus norvegicus [Reaction:R-RNO-9705925] Androgens binds AR (in the HSP90 chaperone complex) - Rattus norvegicus
inferredFrom	[Reaction:R-HSA-193073] HSD2B1 dimer, HSD3B2 dimer isomerise DHA to ANDST - Homo sapiens
input	[SimpleEntity:R-ALL-176626] DHEA [cytosol] [SimpleEntity:R-ALL-29360] NAD+ [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	HSD2B1 dimer, HSD3B2 dimer isomerise DHA to ANDST DHA isomerizes to 4-Androstene3,17-dione
output	[SimpleEntity:R-ALL-193079] ANDST [cytosol] [SimpleEntity:R-ALL-70106] H+ [cytosol] [SimpleEntity:R-ALL-73473] NADH [cytosol]
precedingEvent	[Reaction:R-RNO-193070] CYP17A1 cleaves 17aHPREG to DHA - Rattus norvegicus
regulatedBy	[PositiveRegulation:10122318] Positive regulation by 'POMC(138-176) [cytosol]'
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48895] Rattus norvegicus
stId	R-RNO-193073
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(precedingEvent)	[Reaction:R-RNO-193060] CYP19A1 hydroxylates ANDST to E1 [Reaction:R-RNO-9705925] Androgens binds AR (in the HSP90 chaperone complex) [Reaction:R-RNO-193064] HSD17B3-like proteins reducde ANDST to TEST
(hasEvent)	[Pathway:R-RNO-193048] Androgen biosynthesis
(inferredTo)	[Reaction:R-HSA-193073] HSD2B1 dimer, HSD3B2 dimer isomerise DHA to ANDST

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