Reactome | SRD5A3 dehydrogenates TEST to DHTEST

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SRD5A3 dehydrogenates TEST to DHTEST Show undefined attributes

catalystActivity	[CatalystActivity:10213499] 3-oxo-5-alpha-steroid 4-dehydrogenase activity of SRD5A3 [endoplasmic reticulum membrane]
category	transition
compartment	[Compartment:70101] cytosol [Compartment:12045] endoplasmic reticulum membrane
created	[InstanceEdit:10102717] Weiser, Joel, 2026-03-16
dbId	10213501
displayName	SRD5A3 dehydrogenates TEST to DHTEST
eventOf	[Pathway:R-RNO-193048] Androgen biosynthesis - Rattus norvegicus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-RNO-9705925] Androgens binds AR (in the HSP90 chaperone complex) - Rattus norvegicus
inferredFrom	[Reaction:R-HSA-9705714] SRD5A3 dehydrogenates TEST to DHTEST - Homo sapiens
input	[SimpleEntity:R-ALL-70106] H+ [cytosol] [SimpleEntity:R-ALL-29364] NADPH [cytosol] [SimpleEntity:R-ALL-193057] TEST [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	SRD5A3 dehydrogenates TEST to DHTEST Testosterone is converted to 5-alpha-dihydroxytestosterone
output	[SimpleEntity:R-ALL-469662] DHTEST [cytosol] [SimpleEntity:R-ALL-29366] NADP+ [cytosol]
precedingEvent	[Reaction:R-RNO-193064] HSD17B3-like proteins reducde ANDST to TEST - Rattus norvegicus
regulatedBy	[PositiveRegulation:10122318] Positive regulation by 'POMC(138-176) [cytosol]'
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48895] Rattus norvegicus
stId	R-RNO-9705714
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-RNO-193048] Androgen biosynthesis
(precedingEvent)	[Reaction:R-RNO-9705925] Androgens binds AR (in the HSP90 chaperone complex)
(inferredTo)	[Reaction:R-HSA-9705714] SRD5A3 dehydrogenates TEST to DHTEST

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