Reactome | HSD17B3-like proteins reducde ANDST to TEST

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HSD17B3-like proteins reducde ANDST to TEST Show undefined attributes

catalystActivity	[CatalystActivity:10122313] testosterone dehydrogenase (NADP+) activity of HSD17B3-like Proteins [endoplasmic reticulum membrane]
category	transition
compartment	[Compartment:70101] cytosol [Compartment:12045] endoplasmic reticulum membrane
created	[InstanceEdit:10102717] Weiser, Joel, 2026-03-16
dbId	10122317
displayName	HSD17B3-like proteins reducde ANDST to TEST
eventOf	[Pathway:R-RNO-193048] Androgen biosynthesis - Rattus norvegicus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-RNO-193143] CYP19A1 hydroxylates TEST to EST17b - Rattus norvegicus [Reaction:R-RNO-9705925] Androgens binds AR (in the HSP90 chaperone complex) - Rattus norvegicus [Reaction:R-RNO-469659] SRD5A1 dehydrogenates TEST to DHTEST - Rattus norvegicus [Reaction:R-RNO-9705714] SRD5A3 dehydrogenates TEST to DHTEST - Rattus norvegicus [Reaction:R-RNO-9705713] SRD5A2 dehydrogenates TEST to DHTEST - Rattus norvegicus
inferredFrom	[Reaction:R-HSA-193064] HSD17B3-like proteins reducde ANDST to TEST - Homo sapiens
input	[SimpleEntity:R-ALL-193079] ANDST [cytosol] [SimpleEntity:R-ALL-70106] H+ [cytosol] [SimpleEntity:R-ALL-29364] NADPH [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	HSD17B3-like proteins reducde ANDST to TEST Reduction of androstenedione to testosterone
output	[SimpleEntity:R-ALL-29366] NADP+ [cytosol] [SimpleEntity:R-ALL-193057] TEST [cytosol]
precedingEvent	[Reaction:R-RNO-193073] HSD2B1 dimer, HSD3B2 dimer isomerise DHA to ANDST - Rattus norvegicus [Reaction:R-RNO-193099] CYP17A1 cleaves 17aHPROG to ANDST - Rattus norvegicus
regulatedBy	[PositiveRegulation:10122261] Positive regulation by 'glyco-Lutropin [extracellular region]' [PositiveRegulation:10122318] Positive regulation by 'POMC(138-176) [cytosol]'
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48895] Rattus norvegicus
stId	R-RNO-193064
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(precedingEvent)	[Reaction:R-RNO-193143] CYP19A1 hydroxylates TEST to EST17b [Reaction:R-RNO-9705925] Androgens binds AR (in the HSP90 chaperone complex) [Reaction:R-RNO-469659] SRD5A1 dehydrogenates TEST to DHTEST [Reaction:R-RNO-9705714] SRD5A3 dehydrogenates TEST to DHTEST [Reaction:R-RNO-9705713] SRD5A2 dehydrogenates TEST to DHTEST
(hasEvent)	[Pathway:R-RNO-193048] Androgen biosynthesis
(inferredTo)	[Reaction:R-HSA-193064] HSD17B3-like proteins reducde ANDST to TEST