Reactome | CYP17A1 17-hydroxylates PREG

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CYP17A1 17-hydroxylates PREG Show undefined attributes

catalystActivity	[CatalystActivity:10122326] steroid 17-alpha-monooxygenase activity of CYP17A1 [endoplasmic reticulum membrane]
category	transition
compartment	[Compartment:70101] cytosol [Compartment:12045] endoplasmic reticulum membrane
created	[InstanceEdit:10102717] Weiser, Joel, 2026-03-16
dbId	10122328
displayName	CYP17A1 17-hydroxylates PREG
eventOf	[Pathway:R-RNO-193048] Androgen biosynthesis - Rattus norvegicus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-RNO-196372] 17-Hydroxypregnenolone is dehydrogenated to form pregn-5-ene-3,20-dione-17-ol - Rattus norvegicus [Reaction:R-RNO-193070] CYP17A1 cleaves 17aHPREG to DHA - Rattus norvegicus
inferredFrom	[Reaction:R-HSA-193068] CYP17A1 17-hydroxylates PREG - Homo sapiens
input	[SimpleEntity:R-ALL-70106] H+ [cytosol] [SimpleEntity:R-ALL-29364] NADPH [cytosol] [SimpleEntity:R-ALL-29368] O2 [cytosol] [SimpleEntity:R-ALL-193103] PREG [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	CYP17A1 17-hydroxylates PREG O2 + pregnenolone + reduced (NADPH--hemoprotein reductase) => 17alpha-hydroxypregnenolone + H(+) + H2O + oxidized (NADPH--hemoprotein reductase) Hydroxylation of pregnenolone to form 17alpha-hydroxypregnenolone pregnenolone + NADPH + H+ => 17alpha-hydroxypregnenolone + NADP+ + H2O
output	[SimpleEntity:R-ALL-193124] 17aHPREG [cytosol] [SimpleEntity:R-ALL-29356] H2O [cytosol] [SimpleEntity:R-ALL-29366] NADP+ [cytosol]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48895] Rattus norvegicus
stId	R-RNO-193068
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-RNO-193048] Androgen biosynthesis [Pathway:R-RNO-194002] Glucocorticoid biosynthesis
(precedingEvent)	[Reaction:R-RNO-196372] 17-Hydroxypregnenolone is dehydrogenated to form pregn-5-ene-3,20-dione-17-ol [Reaction:R-RNO-193070] CYP17A1 cleaves 17aHPREG to DHA
(inferredTo)	[Reaction:R-HSA-193068] CYP17A1 17-hydroxylates PREG

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