Reactome | GABAB heterodimeric receptor binds GABA

Schema > Reaction > Entries

GABAB heterodimeric receptor binds GABA Show undefined attributes

category	binding
compartment	[Compartment:876] plasma membrane [Compartment:984] extracellular region
created	[InstanceEdit:9984900] Weiser, Joel, 2026-03-16
dbId	10014826
displayName	GABAB heterodimeric receptor binds GABA
eventOf	[Pathway:R-MMU-977444] GABA B receptor activation - Mus musculus [Pathway:R-MMU-420499] Class C/3 (Metabotropic glutamate/pheromone receptors) - Mus musculus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-MMU-1013013] Association of GABA B receptor with G protein beta-gamma subunits - Mus musculus [Reaction:R-MMU-1013012] Binding of Gbeta/gamma to GIRK/Kir3 channels - Mus musculus [Reaction:R-MMU-749456] Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi - Mus musculus
inferredFrom	[Reaction:R-HSA-420688] GABAB heterodimeric receptor binds GABA - Homo sapiens
input	[SimpleEntity:R-ALL-352003] GABA [extracellular region] [Complex:R-MMU-420748] GABBR1:GABBR2 [plasma membrane]
isInDisease	false
isInferred	true
maxDepth	1
name	GABAB heterodimeric receptor binds GABA
output	[Complex:R-MMU-420698] GABBR1:GABBR2:GABA [plasma membrane]
precedingEvent	[Reaction:R-MMU-888589] Release of GABA at the synapse - Mus musculus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48892] Mus musculus
stId	R-MMU-420688
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-MMU-420499] Class C/3 (Metabotropic glutamate/pheromone receptors) [Pathway:R-MMU-977444] GABA B receptor activation
(precedingEvent)	[Reaction:R-MMU-1013012] Binding of Gbeta/gamma to GIRK/Kir3 channels [Reaction:R-MMU-1013013] Association of GABA B receptor with G protein beta-gamma subunits [Reaction:R-MMU-749456] Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi
(inferredTo)	[Reaction:R-HSA-420688] GABAB heterodimeric receptor binds GABA