Reactome | Ligand:GPCR complexes that activate Gi [plasma membrane]

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Ligand:GPCR complexes that activate Gi [plasma membrane] Show undefined attributes

compartment	[Compartment:876] plasma membrane
componentOf	[Complex:R-MMU-749455] Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] - Mus musculus
consumedByEvent	[Reaction:R-MMU-749456] Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi - Mus musculus
created	[InstanceEdit:9984900] Weiser, Joel, 2026-03-16
dbId	10011647
displayName	Ligand:GPCR complexes that activate Gi [plasma membrane]
hasMember	[Complex:R-MMU-444688] C3AR1:C3a [plasma membrane] - Mus musculus [Complex:R-MMU-389873] AGTR2:AGT(25-32) [plasma membrane] - Mus musculus [Complex:R-MMU-374316] APLNR:Apelin peptides [plasma membrane] - Mus musculus [Complex:R-MMU-374321] Bradykinin receptor:Bradykinin [plasma membrane] - Mus musculus [Complex:R-MMU-375354] C5AR1:C5a [plasma membrane] - Mus musculus [Complex:R-MMU-374150] GPER1:ESTG [plasma membrane] - Mus musculus [Complex:R-MMU-374779] Neuropeptides B/W receptor:neuropeptides B/W [plasma membrane] - Mus musculus [Complex:R-MMU-374725] Nociceptin receptor:Nociceptin [plasma membrane] - Mus musculus [Complex:R-MMU-374302] Opioid receptor:opioid ligand [plasma membrane] - Mus musculus [Complex:R-MMU-373299] CCR3,4,5:CCL5(24-91) [plasma membrane] - Mus musculus [Complex:R-MMU-373236] CCR10:CCL27,28 [plasma membrane] - Mus musculus [Complex:R-MMU-373235] CCR6:CCL20 [plasma membrane] - Mus musculus [Complex:R-MMU-373319] CCR7:CCL19,21 [plasma membrane] - Mus musculus [Complex:R-MMU-373329] CCR9:CCL25 [plasma membrane] - Mus musculus [Complex:R-MMU-373801] CXCR1:CXCR1 ligands [plasma membrane] - Mus musculus [Complex:R-MMU-373773] CXCR2:CXCR2 ligands [plasma membrane] - Mus musculus [Complex:R-MMU-374141] CXCR3:CXCR3 ligands [plasma membrane] - Mus musculus [Complex:R-MMU-374203] CXCR4,7:CXCL12 [plasma membrane] - Mus musculus [Complex:R-MMU-444551] CXCR5:CXCL13 [plasma membrane] - Mus musculus [Complex:R-MMU-373797] CXCR6:CXCL16 [plasma membrane] - Mus musculus [Complex:R-MMU-374763] Somatostatin receptor:somatostatin [plasma membrane] - Mus musculus [Complex:R-MMU-390955] HTR1B,D,E,F,HTR5A:5HT [plasma membrane] - Mus musculus [Complex:R-MMU-390876] HRH4:Hist [plasma membrane] - Mus musculus [Complex:R-MMU-390849] DRD3,4:DA [plasma membrane] - Mus musculus [Complex:R-MMU-390700] ADRA2A,B,C:ADR,NAd [plasma membrane] - Mus musculus [Complex:R-MMU-390685] CHRM2,CHRM4:AcCho [plasma membrane] - Mus musculus [Complex:R-MMU-417869] P2RY4:UTP [plasma membrane] - Mus musculus [Complex:R-MMU-417834] P2RY12:ADP [plasma membrane] - Mus musculus [Complex:R-MMU-417853] P2RY13:ADP [plasma membrane] - Mus musculus [Complex:R-MMU-417863] P2RY14:UDP-Glc [plasma membrane] - Mus musculus [Complex:R-MMU-418897] ADORA1,3:Ade-Rib [plasma membrane] - Mus musculus [Complex:R-MMU-419404] CNRs:Cannabinoids [plasma membrane] - Mus musculus [Complex:R-MMU-420743] CASR:Ca2+ [plasma membrane] - Mus musculus [Complex:R-MMU-389042] GALR1-3:GAL [plasma membrane] - Mus musculus [Complex:R-MMU-416381] GPR17:Cysteinyl leukotrienes [plasma membrane] - Mus musculus [Complex:R-MMU-416875] PTGDR2:PGD2 [plasma membrane] - Mus musculus [Complex:R-MMU-419353] LPAR1,2,3,5:LPA [plasma membrane] - Mus musculus [Complex:R-MMU-419365] Melatonin receptors:melatonin [plasma membrane] - Mus musculus [Complex:R-MMU-388866] Neuropeptide Y receptors:NPY receptor ligands [plasma membrane] - Mus musculus [Complex:R-MMU-391924] PTGER3:PGE2 [plasma membrane] - Mus musculus [Complex:R-MMU-419346] S1PR2-5:S1P [plasma membrane] - Mus musculus [Complex:R-MMU-416459] FPR2:FPR2 ligands [plasma membrane] - Mus musculus [Complex:R-MMU-444509] FPR1:FMLP [plasma membrane] - Mus musculus [Complex:R-MMU-444553] FPR3:FPR3 ligands [plasma membrane] - Mus musculus [Complex:R-MMU-444847] RXFP3:Relaxin-3 [plasma membrane] - Mus musculus [Complex:R-MMU-444907] RXFP4:RXFP4 ligands [plasma membrane] - Mus musculus [Complex:R-MMU-517528] GPR18:NAGLY [plasma membrane] - Mus musculus [Complex:R-MMU-947670] MCHR1,MCHR2:PMCH(147-165) [plasma membrane] - Mus musculus [Complex:R-MMU-981831] NMUR2:NMS [plasma membrane] - Mus musculus [Complex:R-MMU-964802] NMUR1,NMUR2:NMU [plasma membrane] - Mus musculus [Complex:R-MMU-3222582] Group II and III metabotropic gutamate receptors:Glu [plasma membrane] - Mus musculus [Complex:R-MMU-3299631] TAS2Rs:Bitter-tasting compounds [plasma membrane] - Mus musculus [Complex:R-MMU-3296289] SUCNR1:SUCCA [plasma membrane] - Mus musculus [Complex:R-MMU-964778] OXGR1:2OG [plasma membrane] - Mus musculus [Complex:R-MMU-3296263] HCAR1:LACT [plasma membrane] - Mus musculus [Complex:R-MMU-3296315] HCAR2:HCAR2 ligands [plasma membrane] - Mus musculus [Complex:R-MMU-3296296] HCAR3:HCAR3 ligands [plasma membrane] - Mus musculus [Complex:R-MMU-373352] CX3CR1:CX3CL1 [plasma membrane] - Mus musculus [Complex:R-MMU-8862737] CCL13:CCL2,CCR3 [plasma membrane] - Mus musculus [Complex:R-MMU-8851339] CCR8:CCL1 [plasma membrane] - Mus musculus [Complex:R-MMU-8865354] CCL4,(CCL4L):CCR5,CCR1 [plasma membrane] - Mus musculus [Complex:R-MMU-8851784] GPR183:7alpha,25-dihydroxycholesterol [plasma membrane] - Mus musculus [Complex:R-MMU-5336181] GPR37:PSAP fragments [plasma membrane] - Mus musculus [Complex:R-MMU-5336185] GPR37L1:Prosaposin fragments [plasma membrane] - Mus musculus [Complex:R-MMU-3499321] GPR31:12(S)-HETE [plasma membrane] - Mus musculus [Complex:R-MMU-420698] GABBR1:GABBR2:GABA [plasma membrane] - Mus musculus [Complex:R-MMU-444655] TAS1R1:TAS1R3:L-Glu [plasma membrane] - Mus musculus [Complex:R-MMU-444662] TAS1R2:TAS1R3:Sweet taste compounds [plasma membrane] - Mus musculus
inDisease	false
inferredFrom	[DefinedSet:R-HSA-380091] Ligand:GPCR complexes that activate Gi [plasma membrane] - Homo sapiens
maxDepth	5
name	Ligand:GPCR complexes that activate Gi
producedByEvent	[Reaction:R-MMU-749454] The Ligand:GPCR:Gi complex dissociates - Mus musculus
schemaClass	DefinedSet
species	[Species:48892] Mus musculus
stId	R-MMU-380091

Referrals

(hasComponent)	[Complex:R-MMU-749455] Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] [Complex:R-MMU-749445] Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane]
(input)	[Reaction:R-MMU-749456] Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi
(output)	[Reaction:R-MMU-749454] The Ligand:GPCR:Gi complex dissociates
(inferredTo)	[DefinedSet:R-HSA-380091] Ligand:GPCR complexes that activate Gi [plasma membrane]

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