Reactome | Citric acid cycle (TCA cycle)

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Citric acid cycle (TCA cycle) Show undefined attributes

compartment	[Compartment:5462] mitochondrion
created	[InstanceEdit:9984900] Weiser, Joel, 2026-03-16
dbId	10098547
displayName	Citric acid cycle (TCA cycle)
eventOf	[Pathway:R-MMU-1428517] Aerobic respiration and respiratory electron transport - Mus musculus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
goBiologicalProcess	[GO_BiologicalProcess:12759] tricarboxylic acid cycle
hasDiagram	true
hasEHLD	false
hasEvent	[Reaction:R-MMU-70975] CS acetylates OA to citrate - Mus musculus [Reaction:R-MMU-70971] ACO2 isomerizes citrate - Mus musculus [Reaction:R-MMU-70967] IDH3 complex decarboxylates isocitrate - Mus musculus [Reaction:R-MMU-450984] IDH2 dimer decarboxylates isocitrate - Mus musculus [Reaction:R-MMU-450971] NNT dimer transfers proton from NADPH to NAD+ - Mus musculus [Pathway:R-MMU-9853506] OGDH complex synthesizes succinyl-CoA from 2-OG - Mus musculus [Reaction:R-MMU-70997] SUCLG1/A2 cleaves succinyl-CoA - Mus musculus [Reaction:R-MMU-71775] SUCLG1/G2 cleaves succinyl-CoA - Mus musculus [Reaction:R-MMU-70994] SDH complex dehydrogenates succinate - Mus musculus [Reaction:R-MMU-70982] FH tetramer hydrates fumarate to L-malate - Mus musculus [Reaction:R-MMU-70979] MDH2 dimer dehydrogenates MAL - Mus musculus [Pathway:R-MMU-9854311] Maturation of TCA enzymes and regulation of TCA cycle - Mus musculus
inferredFrom	[Pathway:R-HSA-71403] Citric acid cycle (TCA cycle) - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	3
name	Citric acid cycle (TCA cycle)
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:48892] Mus musculus
stId	R-MMU-71403
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEncapsulatedEvent)	[Pathway:R-MMU-9856872] Malate-aspartate shuttle [Pathway:R-MMU-70268] Pyruvate metabolism [Pathway:R-MMU-9857492] Protein lipoylation [Pathway:R-MMU-611105] Respiratory electron transport [Pathway:R-MMU-8963691] Phenylalanine and tyrosine metabolism [Pathway:R-MMU-880009] Interconversion of 2-oxoglutarate and 2-hydroxyglutarate
(inferredTo)	[Pathway:R-HSA-71403] Citric acid cycle (TCA cycle)
(hasEvent)	[Pathway:R-MMU-1428517] Aerobic respiration and respiratory electron transport

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