Reactome | Malate-aspartate shuttle

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Malate-aspartate shuttle Show undefined attributes

compartment	[Compartment:5460] mitochondrial matrix [Compartment:70616] mitochondrial inner membrane [Compartment:70101] cytosol
created	[InstanceEdit:9984900] Weiser, Joel, 2026-03-16
dbId	10098521
displayName	Malate-aspartate shuttle
eventOf	[Pathway:R-MMU-611105] Respiratory electron transport - Mus musculus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
goBiologicalProcess	[GO_BiologicalProcess:172663] malate-aspartate shuttle
hasDiagram	true
hasEHLD	false
hasEvent	[Reaction:R-MMU-372448] SLC25A12,13 exchange L-Glu and L-Asp - Mus musculus [Reaction:R-MMU-70592] PXLP-K259-GOT1 transaminates 2-OG and L-Asp - Mus musculus [Reaction:R-MMU-9856871] MDH1 reduces OA - Mus musculus [Reaction:R-MMU-8875623] SLC25A18,22 import L-Glu, H+ - Mus musculus [Reaction:R-MMU-70613] GOT2 transaminates OA and L-Glu - Mus musculus [Reaction:R-MMU-70979] MDH2 dimer dehydrogenates MAL - Mus musculus [Reaction:R-MMU-376851] SLC25A11 exchanges 2-OG and MAL - Mus musculus
inferredFrom	[Pathway:R-HSA-9856872] Malate-aspartate shuttle - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	2
name	Malate-aspartate shuttle
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:48892] Mus musculus
stId	R-MMU-9856872
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEncapsulatedEvent)	[Pathway:R-MMU-390918] Peroxisomal lipid metabolism [Pathway:R-MMU-70326] Glucose metabolism [Pathway:R-MMU-977347] Serine metabolism [Pathway:R-MMU-71403] Citric acid cycle (TCA cycle)
(inferredTo)	[Pathway:R-HSA-9856872] Malate-aspartate shuttle
(hasEvent)	[Pathway:R-MMU-611105] Respiratory electron transport