Reactome | IDH2 dimer decarboxylates isocitrate

Schema > Reaction > Entries

IDH2 dimer decarboxylates isocitrate Show undefined attributes

catalystActivity	[CatalystActivity:10018993] isocitrate dehydrogenase (NADP+) activity of IDH2 dimer [mitochondrial matrix]
category	transition
compartment	[Compartment:5460] mitochondrial matrix
created	[InstanceEdit:9984900] Weiser, Joel, 2026-03-16
dbId	10019000
displayName	IDH2 dimer decarboxylates isocitrate
eventOf	[Pathway:R-MMU-71403] Citric acid cycle (TCA cycle) - Mus musculus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-MMU-450971] NNT dimer transfers proton from NADPH to NAD+ - Mus musculus [Reaction:R-MMU-1475025] Carbonic anhydrase hydrates carbon dioxide (plasma membrane) - Mus musculus [Reaction:R-MMU-1475026] Carbonic anhydrase hydrates carbon dioxide (cytosol) - Mus musculus [Reaction:R-MMU-1475032] Carbonic anhydrase hydrates carbon dioxide (mitochondria) - Mus musculus [Reaction:R-MMU-1237047] CA4:Zn2+ hydrates CO2 to HCO3- - Mus musculus [Reaction:R-MMU-1237069] RHAG transports CO2 from extracellular region to cytosol - Mus musculus [Reaction:R-MMU-1237042] AQP1 tetramer transports CO2 from extracellular region to cytosol - Mus musculus [Reaction:R-MMU-71401] OGDH dimer decarboxylates 2-OG - Mus musculus
inferredFrom	[Reaction:R-HSA-450984] IDH2 dimer decarboxylates isocitrate - Homo sapiens
input	[SimpleEntity:R-ALL-29938] ISCIT [mitochondrial matrix] [SimpleEntity:R-ALL-113563] NADP+ [mitochondrial matrix]
isInDisease	false
isInferred	true
maxDepth	1
name	IDH2 dimer decarboxylates isocitrate D-threo-isocitrate + NADP(+) => 2-oxoglutarate + CO2 + NADPH
output	[SimpleEntity:R-ALL-113594] 2OG [mitochondrial matrix] [SimpleEntity:R-ALL-29376] CO2 [mitochondrial matrix] [SimpleEntity:R-ALL-113600] NADPH [mitochondrial matrix]
precedingEvent	[Reaction:R-MMU-70971] ACO2 isomerizes citrate - Mus musculus [Reaction:R-MMU-450971] NNT dimer transfers proton from NADPH to NAD+ - Mus musculus
regulatedBy	[NegativeRegulation:10019001] Negative regulation by 'AcK-IDH2 dimer [mitochondrial matrix]'
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48892] Mus musculus
stId	R-MMU-450984
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(precedingEvent)	[Reaction:R-MMU-1475025] Carbonic anhydrase hydrates carbon dioxide (plasma membrane) [Reaction:R-MMU-1475026] Carbonic anhydrase hydrates carbon dioxide (cytosol) [Reaction:R-MMU-1475032] Carbonic anhydrase hydrates carbon dioxide (mitochondria) [Reaction:R-MMU-1237047] CA4:Zn2+ hydrates CO2 to HCO3- [Reaction:R-MMU-1237069] RHAG transports CO2 from extracellular region to cytosol [Reaction:R-MMU-1237042] AQP1 tetramer transports CO2 from extracellular region to cytosol [Reaction:R-MMU-71401] OGDH dimer decarboxylates 2-OG [Reaction:R-MMU-450971] NNT dimer transfers proton from NADPH to NAD+
(hasEvent)	[Pathway:R-MMU-71403] Citric acid cycle (TCA cycle)
(inferredTo)	[Reaction:R-HSA-450984] IDH2 dimer decarboxylates isocitrate

Cite Us!