Reactome | SDH complex dehydrogenates succinate

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SDH complex dehydrogenates succinate Show undefined attributes

catalystActivity	[CatalystActivity:9986804] succinate dehydrogenase (quinone) activity of SDH complex [mitochondrial inner membrane]
category	transition
compartment	[Compartment:5460] mitochondrial matrix [Compartment:70616] mitochondrial inner membrane
created	[InstanceEdit:9984900] Weiser, Joel, 2026-03-16
dbId	9986810
displayName	SDH complex dehydrogenates succinate
eventOf	[Pathway:R-MMU-71403] Citric acid cycle (TCA cycle) - Mus musculus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-MMU-70982] FH tetramer hydrates fumarate to L-malate - Mus musculus
inferredFrom	[Reaction:R-HSA-70994] SDH complex dehydrogenates succinate - Homo sapiens
input	[SimpleEntity:R-ALL-73663] CoQ [mitochondrial inner membrane] [SimpleEntity:R-ALL-113536] SUCCA [mitochondrial matrix]
isInDisease	false
isInferred	true
maxDepth	1
name	SDH complex dehydrogenates succinate Succinate + Q10 => Fumarate + Q10H2
output	[SimpleEntity:R-ALL-2162198] CoQH2 [mitochondrial inner membrane] [SimpleEntity:R-ALL-113588] FUMA [mitochondrial matrix]
precedingEvent	[Reaction:R-MMU-70997] SUCLG1/A2 cleaves succinyl-CoA - Mus musculus [Reaction:R-MMU-71775] SUCLG1/G2 cleaves succinyl-CoA - Mus musculus [Reaction:R-MMU-888548] ALDH5A1 dehydrogenates SUCCSA to SUCCA - Mus musculus [Reaction:R-MMU-9855252] SDHA:SDHB binds to SDHC:SDHD - Mus musculus
regulatedBy	[NegativeRegulation:9986811] Negative regulation by 'TRAP1 [mitochondrial matrix]' [NegativeRegulation:9986812] Negative regulation by 'itaconate [mitochondrial matrix]'
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48892] Mus musculus
stId	R-MMU-70994
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-MMU-71403] Citric acid cycle (TCA cycle)
(precedingEvent)	[Reaction:R-MMU-70982] FH tetramer hydrates fumarate to L-malate
(inferredTo)	[Reaction:R-HSA-70994] SDH complex dehydrogenates succinate