Reactome | phospho-Mdm2 [nucleoplasm]

Schema > EntityWithAccessionedSequence > Entries

compartment	[Compartment:7660] nucleoplasm
componentOf	[Complex:R-MMU-6792868] PPP2A-PPPR5C:CCNG1:(p-T218-MDM2, p-S166-MDM2) [nucleoplasm] - Mus musculus
consumedByEvent	[Reaction:R-MMU-6792871] CCNG1 recruits PP2A-PPP2R5C to MDM2 - Mus musculus
created	[InstanceEdit:9864362] Wright, Adam, 2024-03-07
dbId	9947915
displayName	phospho-Mdm2 [nucleoplasm]
endCoordinate	491
hasModifiedResidue	[ModifiedResidue:9947913] O-phospho-L-threonine at 218 (in Homo sapiens) [ModifiedResidue:9881717] O-phospho-L-serine at 166 (in Homo sapiens) [ModifiedResidue:9881718] O-phospho-L-serine at 188 (in Homo sapiens)
inDisease	false
inferredFrom	[CandidateSet:R-HSA-6792895] p-T218,S166,S188-MDM2, p-S166,S188-MDM2 [nucleoplasm] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-6792862] p-S166,S188,T218-MDM2 [nucleoplasm] - Homo sapiens
name	phospho-Mdm2 p-S166,S188,T218-MDM2 P23804
producedByEvent	[Reaction:R-MMU-6793661] (CDK1,CDK2):CCNA phosphorylates MDM2 at T218 - Mus musculus
referenceEntity	[ReferenceGeneProduct:95019] UniProt:P23804 Mdm2
referenceType	ReferenceGeneProduct
schemaClass	EntityWithAccessionedSequence
species	[Species:48892] Mus musculus
stId	R-MMU-6792862
startCoordinate	1

(input)	[Reaction:R-MMU-6792871] CCNG1 recruits PP2A-PPP2R5C to MDM2
(output)	[Reaction:R-MMU-6793661] (CDK1,CDK2):CCNA phosphorylates MDM2 at T218
(hasComponent)	[Complex:R-MMU-6792868] PPP2A-PPPR5C:CCNG1:(p-T218-MDM2, p-S166-MDM2) [nucleoplasm]
(inferredTo)	[CandidateSet:R-HSA-6792895] p-T218,S166,S188-MDM2, p-S166,S188-MDM2 [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-6792862] p-S166,S188,T218-MDM2 [nucleoplasm]

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