Reactome | XPA [nucleoplasm]

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XPA [nucleoplasm] Show undefined attributes

compartment	[Compartment:7660] nucleoplasm
componentOf	[Complex:R-MMU-5689300] Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1,PAR-PARP2 [nucleoplasm] - Mus musculus [Complex:R-MMU-6790517] Open bubble-dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1, PAR-PARP2:CHD1L [nucleoplasm] - Mus musculus [Complex:R-MMU-6782063] Ubiquitinated,hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:Ub:ERCC6:ERCC8:DDB1:CUL4:RBX1:UVSSA:USP7:XAB2 complex:XPA:TCEA1:HMGN1:EP300 [nucleoplasm] - Mus musculus [Complex:R-MMU-5690214] GG-NER incision complex:5'-incised damaged DNA:(PCNA:POLD,POLE),(MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] - Mus musculus [Complex:R-MMU-6782205] TC-NER incision complex:5'-incised damaged DNA:trimmed nascent mRNA [nucleoplasm] - Mus musculus [Complex:R-MMU-6782219] TC-NER incision complex: 5'-incised damaged DNA:trimmed nascent mRNA:(PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] - Mus musculus
consumedByEvent	[Reaction:R-MMU-5689861] Recruitment of XPA and release of CAK - Mus musculus [Reaction:R-MMU-6782004] Assembly of the pre-incision complex in TC-NER - Mus musculus
created	[InstanceEdit:9984900] Weiser, Joel, 2026-03-16
dbId	10061912
displayName	XPA [nucleoplasm]
endCoordinate	273
inDisease	false
inferredFrom	[EntityWithAccessionedSequence:R-HSA-67437] XPA [nucleoplasm] - Homo sapiens
maxDepth	1
name	XPA Q64267
producedByEvent	[Reaction:R-MMU-6782224] 3' incision by ERCC5 (XPG) in TC-NER - Mus musculus [Reaction:R-MMU-5690988] 3'-incision of DNA by ERCC5 (XPG) in GG-NER - Mus musculus
referenceEntity	[ReferenceGeneProduct:uniprot:Q64267] UniProt:Q64267
referenceType	ReferenceGeneProduct
schemaClass	EntityWithAccessionedSequence
species	[Species:48892] Mus musculus
stId	R-MMU-67437
startCoordinate	2

Referrals

(output)	[Reaction:R-MMU-6782224] 3' incision by ERCC5 (XPG) in TC-NER [Reaction:R-MMU-5690988] 3'-incision of DNA by ERCC5 (XPG) in GG-NER
(hasComponent)	[Complex:R-MMU-6782219] TC-NER incision complex: 5'-incised damaged DNA:trimmed nascent mRNA:(PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] [Complex:R-MMU-6782205] TC-NER incision complex:5'-incised damaged DNA:trimmed nascent mRNA [nucleoplasm] [Complex:R-MMU-6782063] Ubiquitinated,hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:Ub:ERCC6:ERCC8:DDB1:CUL4:RBX1:UVSSA:USP7:XAB2 complex:XPA:TCEA1:HMGN1:EP300 [nucleoplasm] [Complex:R-MMU-6782066] TC-NER pre-incision complex [nucleoplasm] [Complex:R-MMU-6782111] TC-NER pre-incision complex:Open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm] [Complex:R-MMU-9684117] TC-NER pre-incision complex:Partially open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm] [Complex:R-MMU-5689300] Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1,PAR-PARP2 [nucleoplasm] [Complex:R-MMU-5691018] Ub:XPC:RAD23:CETN2:Open bubble-dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1,PAR-PARP2:CHD1L [nucleoplasm] [Complex:R-MMU-6790468] Ub,SUMO:XPC:RAD23:CETN2:Open bubble-dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1, PAR-PARP2:CHD1L [nucleoplasm] [Complex:R-MMU-6790517] Open bubble-dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1, PAR-PARP2:CHD1L [nucleoplasm] [Complex:R-MMU-5691059] GG-NER incision complex:5'-incised damaged DNA [nucleoplasm] [Complex:R-MMU-5690214] GG-NER incision complex:5'-incised damaged DNA:(PCNA:POLD,POLE),(MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm]
(input)	[Reaction:R-MMU-6782004] Assembly of the pre-incision complex in TC-NER [Reaction:R-MMU-5689861] Recruitment of XPA and release of CAK
(inferredTo)	[EntityWithAccessionedSequence:R-HSA-67437] XPA [nucleoplasm]

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