Reactome | XPA [nucleoplasm]

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XPA [nucleoplasm] Show undefined attributes

compartment	[Compartment:7660] nucleoplasm
componentOf	[Complex:R-HSA-5691059] GG-NER incision complex:5'-incised damaged DNA [nucleoplasm] - Homo sapiens [Complex:R-HSA-6790517] Open bubble-dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1, PAR-PARP2:CHD1L [nucleoplasm] - Homo sapiens [Complex:R-HSA-6782111] TC-NER pre-incision complex:Open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm] - Homo sapiens [Complex:R-HSA-5690214] GG-NER incision complex:5'-incised damaged DNA:(PCNA:POLD,POLE),(MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] - Homo sapiens [Complex:R-HSA-6782205] TC-NER incision complex:5'-incised damaged DNA:trimmed nascent mRNA [nucleoplasm] - Homo sapiens [Complex:R-HSA-6782219] TC-NER incision complex: 5'-incised damaged DNA:trimmed nascent mRNA:(PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] - Homo sapiens
consumedByEvent	[Reaction:R-HSA-5689861] Recruitment of XPA and release of CAK - Homo sapiens [Reaction:R-HSA-6782004] Assembly of the pre-incision complex in TC-NER - Homo sapiens
dbId	67437
displayName	XPA [nucleoplasm]
endCoordinate	273
inDisease	false
inferredTo	[EntityWithAccessionedSequence:R-MMU-67437] XPA [nucleoplasm] - Mus musculus [EntityWithAccessionedSequence:R-RNO-67437] Xpa [nucleoplasm] - Rattus norvegicus [EntityWithAccessionedSequence:R-CFA-67437] XPA [nucleoplasm] - Canis familiaris [EntityWithAccessionedSequence:R-BTA-67437] XPA [nucleoplasm] - Bos taurus [EntityWithAccessionedSequence:R-SSC-67437] XPA [nucleoplasm] - Sus scrofa [EntityWithAccessionedSequence:R-DRE-67437] xpa [nucleoplasm] - Danio rerio [EntityWithAccessionedSequence:R-XTR-67437] xpa [nucleoplasm] - Xenopus tropicalis [EntityWithAccessionedSequence:R-GGA-67437] XPA [nucleoplasm] - Gallus gallus [EntityWithAccessionedSequence:R-DME-67437] XPA [nucleoplasm] - Drosophila melanogaster [EntityWithAccessionedSequence:R-CEL-67437] xpa-1 [nucleoplasm] - Caenorhabditis elegans [GenomeEncodedEntity:R-DDI-67437] Ghost homologue of XPA [nucleoplasm] - Dictyostelium discoideum [EntityWithAccessionedSequence:R-SPO-67437] XPA [nucleoplasm] - Schizosaccharomyces pombe [EntityWithAccessionedSequence:R-SCE-67437] XPA [nucleoplasm] - Saccharomyces cerevisiae [EntityWithAccessionedSequence:R-PFA-67437] XPA [nucleoplasm] - Plasmodium falciparum
maxDepth	1
modified	[InstanceEdit:4085262] Orlic-Milacic, M, 2013-08-02
name	XPA XPA protein DNA-repair protein complementing XP-A cells (Xeroderma pigmentosum group A complementing protein) xeroderma pigmentosum, complementation group A DNA-repair protein complementing XP-A cells Xeroderma pigmentosum group A complementing protein
producedByEvent	[Reaction:R-HSA-6782224] 3' incision by ERCC5 (XPG) in TC-NER - Homo sapiens [Reaction:R-HSA-5690988] 3'-incision of DNA by ERCC5 (XPG) in GG-NER - Homo sapiens
referenceEntity	[ReferenceGeneProduct:uniprot:P23025] UniProt:P23025 XPA
referenceType	ReferenceGeneProduct
schemaClass	EntityWithAccessionedSequence
species	[Species:48887] Homo sapiens
stId	R-HSA-67437
startCoordinate	2
updateTrackers	[UpdateTracker:9888559] Update Tracker - [EntityWithAccessionedSequence:67437] XPA [nucleoplasm] - v46:[modifyName] [UpdateTracker:9881130] Update Tracker - [EntityWithAccessionedSequence:67437] XPA [nucleoplasm] - v45:[addName] [UpdateTracker:9874910] Update Tracker - [EntityWithAccessionedSequence:67437] XPA [nucleoplasm] - v44:[modifyEndCoordinate, modifyStartCoordinate]

Referrals

(updatedInstance)	[UpdateTracker:9888559] Update Tracker - [EntityWithAccessionedSequence:67437] XPA [nucleoplasm] - v46:[modifyName] [UpdateTracker:9881130] Update Tracker - [EntityWithAccessionedSequence:67437] XPA [nucleoplasm] - v45:[addName] [UpdateTracker:9874910] Update Tracker - [EntityWithAccessionedSequence:67437] XPA [nucleoplasm] - v44:[modifyEndCoordinate, modifyStartCoordinate]
(output)	[Reaction:R-HSA-6782224] 3' incision by ERCC5 (XPG) in TC-NER [Reaction:R-HSA-5690988] 3'-incision of DNA by ERCC5 (XPG) in GG-NER
(hasComponent)	[Complex:R-HSA-6782219] TC-NER incision complex: 5'-incised damaged DNA:trimmed nascent mRNA:(PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] [Complex:R-HSA-6782205] TC-NER incision complex:5'-incised damaged DNA:trimmed nascent mRNA [nucleoplasm] [Complex:R-HSA-6782111] TC-NER pre-incision complex:Open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm] [Complex:R-HSA-9684117] TC-NER pre-incision complex:Partially open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm] [Complex:R-HSA-6782066] TC-NER pre-incision complex [nucleoplasm] [Complex:R-HSA-6782063] Ubiquitinated,hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:Ub:ERCC6:ERCC8:DDB1:CUL4:RBX1:UVSSA:USP7:XAB2 complex:XPA:TCEA1:HMGN1:EP300 [nucleoplasm] [Complex:R-HSA-5690214] GG-NER incision complex:5'-incised damaged DNA:(PCNA:POLD,POLE),(MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] [Complex:R-HSA-5691059] GG-NER incision complex:5'-incised damaged DNA [nucleoplasm] [Complex:R-HSA-6790517] Open bubble-dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1, PAR-PARP2:CHD1L [nucleoplasm] [Complex:R-HSA-6790468] Ub,SUMO:XPC:RAD23:CETN2:Open bubble-dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1, PAR-PARP2:CHD1L [nucleoplasm] [Complex:R-HSA-5691018] Ub:XPC:RAD23:CETN2:Open bubble-dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1,PAR-PARP2:CHD1L [nucleoplasm] [Complex:R-HSA-5689300] Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1,PAR-PARP2 [nucleoplasm]
(input)	[Reaction:R-HSA-6782004] Assembly of the pre-incision complex in TC-NER [Reaction:R-HSA-5689861] Recruitment of XPA and release of CAK

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