Reactome | 3'-incision of DNA by ERCC5 (XPG) in GG-NER

Schema > Reaction > Entries

3'-incision of DNA by ERCC5 (XPG) in GG-NER Show undefined attributes

catalystActivity	[CatalystActivity:10062802] DNA endonuclease activity of GG-NER incision complex:5'-incised damaged DNA:(PCNA:POLD,POLE),(MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm]
category	transition
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:9984900] Weiser, Joel, 2026-03-16
dbId	10062804
displayName	3'-incision of DNA by ERCC5 (XPG) in GG-NER
eventOf	[Pathway:R-MMU-5696400] Dual Incision in GG-NER - Mus musculus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-MMU-5691001] Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in GG-NER - Mus musculus
goBiologicalProcess	[GO_BiologicalProcess:17134] nucleotide-excision repair
inferredFrom	[Reaction:R-HSA-5690988] 3'-incision of DNA by ERCC5 (XPG) in GG-NER - Homo sapiens
input	[Complex:R-MMU-5690214] GG-NER incision complex:5'-incised damaged DNA:(PCNA:POLD,POLE),(MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm]
isInDisease	false
isInferred	true
maxDepth	1
name	3'-incision of DNA by ERCC5 (XPG) in GG-NER
output	[Complex:R-MMU-5690478] (PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC:Incised DNA without lesion [nucleoplasm] [EntityWithAccessionedSequence:R-MMU-5688916] CHD1L [nucleoplasm] [Complex:R-MMU-109943] ERCC1:ERCC4 [nucleoplasm] [EntityWithAccessionedSequence:R-MMU-67447] ERCC5 [nucleoplasm] [OtherEntity:R-ALL-109960] excised DNA fragment with lesion [nucleoplasm] [Complex:R-MMU-5651709] PAR-PARP1,PAR-PARP2 dimers [nucleoplasm] [Complex:R-MMU-5696649] PAR-UV-DDB [nucleoplasm] [Complex:R-MMU-5689624] TFIIH Core [nucleoplasm] [EntityWithAccessionedSequence:R-MMU-67437] XPA [nucleoplasm]
precedingEvent	[Reaction:R-MMU-5690213] DNA polymerases delta, epsilon or kappa bind the GG-NER site - Mus musculus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48892] Mus musculus
stId	R-MMU-5690988
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-MMU-5696400] Dual Incision in GG-NER
(precedingEvent)	[Reaction:R-MMU-5691001] Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in GG-NER
(inferredTo)	[Reaction:R-HSA-5690988] 3'-incision of DNA by ERCC5 (XPG) in GG-NER