Reactome | Recruitment of XPA and release of CAK

Schema > Reaction > Entries

Recruitment of XPA and release of CAK Show undefined attributes

category	transition
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:9984900] Weiser, Joel, 2026-03-16
dbId	10062041
displayName	Recruitment of XPA and release of CAK
eventOf	[Pathway:R-MMU-5696395] Formation of Incision Complex in GG-NER - Mus musculus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-MMU-5696670] CHD1L is recruited to GG-NER site - Mus musculus
goBiologicalProcess	[GO_BiologicalProcess:17148] nucleotide-excision repair, preincision complex assembly
inferredFrom	[Reaction:R-HSA-5689861] Recruitment of XPA and release of CAK - Homo sapiens
input	[Complex:R-MMU-5689862] Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB:TFIIH:PAR-PARP1,PAR-PARP2 [nucleoplasm] [EntityWithAccessionedSequence:R-MMU-67437] XPA [nucleoplasm]
isInDisease	false
isInferred	true
maxDepth	1
name	Recruitment of XPA and release of CAK
output	[Complex:R-MMU-69221] CAK [nucleoplasm] [Complex:R-MMU-5689300] Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1,PAR-PARP2 [nucleoplasm]
precedingEvent	[Reaction:R-MMU-5691000] TFIIH binds GG-NER site to form a verification complex - Mus musculus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48892] Mus musculus
stId	R-MMU-5689861
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-MMU-5696395] Formation of Incision Complex in GG-NER
(precedingEvent)	[Reaction:R-MMU-5696670] CHD1L is recruited to GG-NER site
(inferredTo)	[Reaction:R-HSA-5689861] Recruitment of XPA and release of CAK

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