Reactome | SIRT6 deacetylates RBBP8

Schema > BlackBoxEvent > Entries

SIRT6 deacetylates RBBP8 Show undefined attributes

catalystActivity	[CatalystActivity:10061082] NAD-dependent protein lysine deacetylase activity of SIRT6 [nucleoplasm]
category	omitted
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:9984900] Weiser, Joel, 2026-03-16
dbId	10061084
displayName	SIRT6 deacetylates RBBP8
eventOf	[Pathway:R-MMU-5693607] Processing of DNA double-strand break ends - Mus musculus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Pathway:R-MMU-5685939] HDR through MMEJ (alt-NHEJ) - Mus musculus [Reaction:R-MMU-5687465] MRN complex binds RBBP8 - Mus musculus [Reaction:R-MMU-5684081] MRN complex binds CDK2 and RBBP8 - Mus musculus
inferredFrom	[BlackBoxEvent:R-HSA-5685953] SIRT6 deacetylates RBBP8 - Homo sapiens
input	[Complex:R-MMU-5685960] Ac-K-RBBP8 homotetramer [nucleoplasm] 4 × [SimpleEntity:R-ALL-427523] NAD+ [nucleoplasm]
isInDisease	false
isInferred	true
maxDepth	1
name	SIRT6 deacetylates RBBP8
output	4 × [SimpleEntity:R-ALL-427498] 2'-O-acetyl-ADP-ribose [nucleoplasm] 4 × [SimpleEntity:R-ALL-427497] NAM [nucleoplasm] [Complex:R-MMU-5684097] RBBP8 homotetramer [nucleoplasm]
releaseDate	2026-03-25
schemaClass	BlackBoxEvent
species	[Species:48892] Mus musculus
stId	R-MMU-5685953
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(precedingEvent)	[Pathway:R-MMU-5685939] HDR through MMEJ (alt-NHEJ) [Reaction:R-MMU-5687465] MRN complex binds RBBP8 [Reaction:R-MMU-5684081] MRN complex binds CDK2 and RBBP8
(hasEvent)	[Pathway:R-MMU-5693607] Processing of DNA double-strand break ends
(inferredTo)	[BlackBoxEvent:R-HSA-5685953] SIRT6 deacetylates RBBP8