Reactome | MRN complex binds RBBP8

Schema > Reaction > Entries

MRN complex binds RBBP8 Show undefined attributes

category	binding
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:9984900] Weiser, Joel, 2026-03-16
dbId	10061508
displayName	MRN complex binds RBBP8
eventOf	[Pathway:R-MMU-5685939] HDR through MMEJ (alt-NHEJ) - Mus musculus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-MMU-5687464] MRN and RBBP8 resect DNA DSBs in MMEJ - Mus musculus
inferredFrom	[Reaction:R-HSA-5687465] MRN complex binds RBBP8 - Homo sapiens
input	[Complex:R-MMU-3785763] DNA DSBs:MRN [nucleoplasm] [Complex:R-MMU-5684097] RBBP8 homotetramer [nucleoplasm]
isInDisease	false
isInferred	true
maxDepth	1
name	MRN complex binds RBBP8
output	[Complex:R-MMU-5687468] DNA DSB:MRN:RBBP8 [nucleoplasm]
precedingEvent	[BlackBoxEvent:R-MMU-5685953] SIRT6 deacetylates RBBP8 - Mus musculus [Reaction:R-MMU-3785768] MRN complex binds DNA double strand breaks - Mus musculus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48892] Mus musculus
stId	R-MMU-5687465
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-MMU-5685939] HDR through MMEJ (alt-NHEJ)
(precedingEvent)	[Reaction:R-MMU-5687464] MRN and RBBP8 resect DNA DSBs in MMEJ
(inferredTo)	[Reaction:R-HSA-5687465] MRN complex binds RBBP8

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