Reactome | HDR through MMEJ (alt-NHEJ)

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HDR through MMEJ (alt-NHEJ) Show undefined attributes

created	[InstanceEdit:9984900] Weiser, Joel, 2026-03-16
dbId	10101309
displayName	HDR through MMEJ (alt-NHEJ)
eventOf	[Pathway:R-MMU-5693538] Homology Directed Repair - Mus musculus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
hasDiagram	true
hasEHLD	false
hasEvent	[Reaction:R-MMU-5687465] MRN complex binds RBBP8 - Mus musculus [Reaction:R-MMU-5687464] MRN and RBBP8 resect DNA DSBs in MMEJ - Mus musculus [Reaction:R-MMU-5687484] PARP1 or PARP2, FEN1 and POLQ are recruited to MMEJ site - Mus musculus [Reaction:R-MMU-5687640] POLQ extends annealed 3'-ssDNA overhangs in MMEJ - Mus musculus [Reaction:R-MMU-5687653] PARP1,PARP2 dimers bound to MMEJ sites autoPARylate - Mus musculus [Reaction:R-MMU-5687664] FEN1 cleaves displaced ssDNA flaps during MMEJ - Mus musculus [Reaction:R-MMU-5687673] MRN recruits LIG3:XRCC1 to MMEJ sites - Mus musculus [Reaction:R-MMU-5687675] LIG3 ligates remaining SSBs in MMEJ - Mus musculus
inferredFrom	[Pathway:R-HSA-5685939] HDR through MMEJ (alt-NHEJ) - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	2
name	HDR through MMEJ (alt-NHEJ)
precedingEvent	[BlackBoxEvent:R-MMU-5685953] SIRT6 deacetylates RBBP8 - Mus musculus [Reaction:R-MMU-3785768] MRN complex binds DNA double strand breaks - Mus musculus
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:48892] Mus musculus
stId	R-MMU-5685939
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-MMU-5693538] Homology Directed Repair
(inferredTo)	[Pathway:R-HSA-5685939] HDR through MMEJ (alt-NHEJ)
(hasEncapsulatedEvent)	[Pathway:R-MMU-5693606] DNA Double Strand Break Response

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