Reactome | Processing of DNA double-strand break ends

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Processing of DNA double-strand break ends Show undefined attributes

compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:9984900] Weiser, Joel, 2026-03-16
dbId	10101295
displayName	Processing of DNA double-strand break ends
eventOf	[Pathway:R-MMU-5693567] HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) - Mus musculus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Pathway:R-MMU-5685942] HDR through Homologous Recombination (HRR) - Mus musculus [Pathway:R-MMU-5685938] HDR through Single Strand Annealing (SSA) - Mus musculus
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-MMU-5684052] PIAS4 SUMOylates MDC1 - Mus musculus [Reaction:R-MMU-5684071] RNF4 ubiquitinates MDC1 - Mus musculus [BlackBoxEvent:R-MMU-5685953] SIRT6 deacetylates RBBP8 - Mus musculus [Reaction:R-MMU-5684081] MRN complex binds CDK2 and RBBP8 - Mus musculus [Reaction:R-MMU-5684096] CDK2 phosphorylates RBBP8 - Mus musculus [Reaction:R-MMU-5684140] ATM phosphorylates RBBP8 - Mus musculus [Reaction:R-MMU-5684108] BRCA1 binds phosphorylated RBBP8 - Mus musculus [Reaction:R-MMU-5693608] Initial resection of double-strand break ends - Mus musculus [Reaction:R-MMU-5685985] EXO1 or DNA2 in complex with BLM or WRN binds initially resected DNA DSBs along with BRIP1 recruitment - Mus musculus [Reaction:R-MMU-5685994] Long-range resection of DNA DSBs by EXO1 or DNA2 - Mus musculus [Reaction:R-MMU-5693542] Association of RPA complexes with ssDNA at resected DNA DSBs - Mus musculus [Reaction:R-MMU-5684875] Binding of ATR:ATRIP to RPA at resected DNA DSBs - Mus musculus [Reaction:R-MMU-5685011] ATR activation at DNA DSBs - Mus musculus [Reaction:R-MMU-5685156] ATR phosphorylates RPA2 - Mus musculus [Reaction:R-MMU-5684882] CHEK1 is recruited to resected DNA DSBs - Mus musculus [Reaction:R-MMU-5684887] Activation of CHEK1 at resected DNA DSBs - Mus musculus [Reaction:R-MMU-5687758] PPP4C:PPP4R2 dephosphorylates RPA2 - Mus musculus
inferredFrom	[Pathway:R-HSA-5693607] Processing of DNA double-strand break ends - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	2
name	Processing of DNA double-strand break ends
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:48892] Mus musculus
stId	R-MMU-5693607
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-MMU-5693567] HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA)
(precedingEvent)	[Pathway:R-MMU-5685942] HDR through Homologous Recombination (HRR) [Pathway:R-MMU-5685938] HDR through Single Strand Annealing (SSA)
(inferredTo)	[Pathway:R-HSA-5693607] Processing of DNA double-strand break ends

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