Reactome | SIRT6 deacetylates RBBP8

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SIRT6 deacetylates RBBP8 Show undefined attributes

authored	[InstanceEdit:5692524] Orlic-Milacic, Marija, 2015-05-12
catalystActivity	[CatalystActivity:5685961] NAD-dependent protein lysine deacetylase activity of SIRT6 [nucleoplasm]
category	uncertain
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:5685957] Orlic-Milacic, Marija, 2015-03-31
dbId	5685953
displayName	SIRT6 deacetylates RBBP8
edited	[InstanceEdit:5692524] Orlic-Milacic, Marija, 2015-05-12 [InstanceEdit:9851696] Orlic-Milacic, Marija, 2023-10-30
eventOf	[Pathway:R-HSA-5693607] Processing of DNA double-strand break ends - Homo sapiens
followingEvent	[Pathway:R-HSA-5685939] HDR through MMEJ (alt-NHEJ) - Homo sapiens [Reaction:R-HSA-5687465] MRN complex binds RBBP8 - Homo sapiens [Reaction:R-HSA-5684081] MRN complex binds CDK2 and RBBP8 - Homo sapiens
input	[Complex:R-HSA-5685960] Ac-K-RBBP8 homotetramer [nucleoplasm] 4 × [SimpleEntity:R-ALL-427523] NAD+ [nucleoplasm]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:9851385] Depletion of SIRT6 enzymatic activity increases acute myeloid leukemia cells' vulnerability to DNA-damaging agents [LiteratureReference:9851360] Lamin A Is an Endogenous SIRT6 Activator and Promotes SIRT6-Mediated DNA Repair [LiteratureReference:9851371] The mechanism of radiotherapy for lung adenocarcinoma in promoting protein SIRT6-mediated deacetylation of RBBP8 to enhance the sensitivity of targeted therapy
maxDepth	1
modified	[InstanceEdit:10914110] Weiser, Joel, 2026-03-16
name	SIRT6 deacetylates RBBP8
orthologousEvent	[BlackBoxEvent:R-MMU-5685953] SIRT6 deacetylates RBBP8 - Mus musculus [BlackBoxEvent:R-CEL-5685953] SIRT6 deacetylates RBBP8 - Caenorhabditis elegans [BlackBoxEvent:R-GGA-5685953] SIRT6 deacetylates RBBP8 - Gallus gallus [BlackBoxEvent:R-XTR-5685953] SIRT6 deacetylates RBBP8 - Xenopus tropicalis [BlackBoxEvent:R-DRE-5685953] SIRT6 deacetylates RBBP8 - Danio rerio [BlackBoxEvent:R-SSC-5685953] SIRT6 deacetylates RBBP8 - Sus scrofa [BlackBoxEvent:R-BTA-5685953] SIRT6 deacetylates RBBP8 - Bos taurus [BlackBoxEvent:R-CFA-5685953] SIRT6 deacetylates RBBP8 - Canis familiaris [BlackBoxEvent:R-RNO-5685953] SIRT6 deacetylates RBBP8 - Rattus norvegicus
output	4 × [SimpleEntity:R-ALL-427498] 2'-O-acetyl-ADP-ribose [nucleoplasm] 4 × [SimpleEntity:R-ALL-427497] NAM [nucleoplasm] [Complex:R-HSA-5684097] RBBP8 homotetramer [nucleoplasm]
previousReviewStatus	[ReviewStatus:9821385] four stars
releaseDate	2015-09-22
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:5693179] Borowiec, James A, 2015-06-12 [InstanceEdit:9851937] Mak, Anthony, 2023-11-02
schemaClass	BlackBoxEvent
species	[Species:48887] Homo sapiens
stId	R-HSA-5685953
summation	[Summation:5685964] Deacteylation of RBBP8 (CtIP) upon DNA damage is dependent o...
updateTrackers	[UpdateTracker:9853276] Update Tracker - [BlackBoxEvent:5685953] SIRT6 deacetylates RBBP8 - v87:[add_removeLiteratureReference, modifyText] [UpdateTracker:9775782] Update Tracker - [Reaction:5685953] SIRT6 deacetylates RBBP8 - v78:[modifyText]

Referrals

(updatedInstance)	[UpdateTracker:9853276] Update Tracker - [BlackBoxEvent:5685953] SIRT6 deacetylates RBBP8 - v87:[add_removeLiteratureReference, modifyText] [UpdateTracker:9775782] Update Tracker - [Reaction:5685953] SIRT6 deacetylates RBBP8 - v78:[modifyText]
(precedingEvent)	[Pathway:R-HSA-5685939] HDR through MMEJ (alt-NHEJ) [Reaction:R-HSA-5687465] MRN complex binds RBBP8 [Reaction:R-HSA-5684081] MRN complex binds CDK2 and RBBP8
(hasEvent)	[Pathway:R-HSA-5693607] Processing of DNA double-strand break ends

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