Reactome | NS2B [endoplasmic reticulum membrane]

Schema > EntityWithAccessionedSequence > Entries

compartment	[Compartment:12045] endoplasmic reticulum membrane
componentOf	[Complex:R-DVI-9918803] NS345:NS2B [endoplasmic reticulum membrane] - Dengue virus type 2 [Complex:R-HSA-9920820] NS2B:CGAS [cytosol] - Homo sapiens
consumedByEvent	[Reaction:R-HSA-9918798] NS2B binds to NS345 - Homo sapiens [Reaction:R-HSA-9918807] NS2B binds NS3 - Homo sapiens [Reaction:R-HSA-9920882] NS2B binds CGAS - Homo sapiens [BlackBoxEvent:R-HSA-9920087] Nonstructural proteins form the replication complex - Homo sapiens
created	[InstanceEdit:9918778] Stephan, Ralf, 2024-08-18
dbId	9918774
displayName	NS2B [endoplasmic reticulum membrane]
endCoordinate	1475
hasModifiedResidue	[ModifiedResidue:9918816] (2S,4R)-4-hydroxyproline at 1348 [ModifiedResidue:9918786] (2S,4R)-4-hydroxyproline at 1376
inDisease	false
maxDepth	1
modified	[InstanceEdit:9945213] Stephan, Ralf, 2025-04-11
name	NS2B
producedByEvent	[Reaction:R-HSA-9918817] NS2B3 cleaves polyprotein - Homo sapiens [Reaction:R-HSA-9918772] Dengue polyprotein cis-auto-cleaves - Homo sapiens
referenceEntity	[ReferenceGeneProduct:uniprot:P29990] UniProt:P29990 Unknown
referenceType	ReferenceGeneProduct
schemaClass	EntityWithAccessionedSequence
species	[Species:3244621] Dengue virus type 2
stId	R-DVI-9918774
startCoordinate	1346

(hasComponent)	[Complex:R-HSA-9920820] NS2B:CGAS [cytosol] [Complex:R-DVI-9979859] Replication complex (RC) [endoplasmic reticulum membrane] [Complex:R-DVI-9918803] NS345:NS2B [endoplasmic reticulum membrane]
(input)	[Reaction:R-HSA-9920882] NS2B binds CGAS [Reaction:R-HSA-9918798] NS2B binds to NS345 [Reaction:R-HSA-9918807] NS2B binds NS3 [BlackBoxEvent:R-HSA-9920087] Nonstructural proteins form the replication complex
(output)	[Reaction:R-HSA-9918817] NS2B3 cleaves polyprotein [Reaction:R-HSA-9918772] Dengue polyprotein cis-auto-cleaves

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