Reactome | NS2B3 [cytosol]

catalystActivities	[CatalystActivity:9919951] serine-type endopeptidase activity of NS2B3 [cytosol]
compartment	[Compartment:70101] cytosol
componentOf	[Complex:R-HSA-9921158] NS2B3:NFKBIA [cytosol] - Homo sapiens [Complex:R-HSA-9921161] NS2B3:NFKBIB [cytosol] - Homo sapiens
consumedByEvent	[Reaction:R-HSA-3244618] DENV protease NS2B3 binds STING - Homo sapiens [BlackBoxEvent:R-HSA-9945387] NS2B3 localizes to nucleus - Homo sapiens [Reaction:R-HSA-9921160] NS2B3 binds NFKBIB - Homo sapiens [Reaction:R-HSA-9921168] NS2B3 binds NFKBIA - Homo sapiens [Reaction:R-HSA-9920952] NS2B3 binds IKBKE - Homo sapiens [Reaction:R-HSA-9954667] NS2B3 binds Dengue protease inhibitors - Homo sapiens
created	[InstanceEdit:3244632] Shamovsky, V, 2013-03-28
crossReference	[DatabaseIdentifier:12020825] Mondo:0005502
dbId	3244638
disease	[Disease:3244610] dengue disease
displayName	NS2B3 [cytosol]
hasComponent	[EntityWithAccessionedSequence:R-DVI-3244645] K27polyUb-NS3 [endoplasmic reticulum membrane] [EntityWithAccessionedSequence:R-DVI-9945382] NS2B [cytosol]
inDisease	true
includedLocation	[Compartment:12045] endoplasmic reticulum membrane
isChimeric	false
literatureReference	[LiteratureReference:3244639] Purified NS2B/NS3 serine protease of dengue virus type 2 exhibits cofactor NS2B dependence for cleavage of substrates with dibasic amino acids in vitro
maxDepth	2
modified	[InstanceEdit:9969615] Stephan, Ralf, 2025-10-23
name	NS2B3
producedByEvent	[BlackBoxEvent:R-HSA-3244626] DENV protease NS2B3 cleaves STING - Homo sapiens [Reaction:R-HSA-9918807] NS2B binds NS3 - Homo sapiens
schemaClass	Complex
species	[Species:3244621] Dengue virus type 2
stId	R-DVI-3244638

(hasComponent)	[Complex:R-HSA-9921161] NS2B3:NFKBIB [cytosol] [Complex:R-HSA-9921158] NS2B3:NFKBIA [cytosol] [Complex:R-HSA-9920946] NS2B3:IKBKE [cytosol] [Complex:R-HSA-3244608] NS2B3:STING [endoplasmic reticulum membrane] [Complex:R-DVI-9954660] NS2B3:Dengue protease inhibitor [cytosol]
(input)	[Reaction:R-HSA-9921160] NS2B3 binds NFKBIB [Reaction:R-HSA-9921168] NS2B3 binds NFKBIA [Reaction:R-HSA-9920952] NS2B3 binds IKBKE [Reaction:R-HSA-3244618] DENV protease NS2B3 binds STING [BlackBoxEvent:R-HSA-9945387] NS2B3 localizes to nucleus [Reaction:R-HSA-9954667] NS2B3 binds Dengue protease inhibitors
(output)	[BlackBoxEvent:R-HSA-3244626] DENV protease NS2B3 cleaves STING [Reaction:R-HSA-9918807] NS2B binds NS3
(activeUnit)	[CatalystActivity:3244661] serine-type endopeptidase activity of NS2B3:STING [endoplasmic reticulum membrane]
(physicalEntity)	[CatalystActivity:9919951] serine-type endopeptidase activity of NS2B3 [cytosol]

NS2B3 [cytosol] Show undefined attributes

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