Reactome | Antigen processing: Ubiquitination & Proteasome degradation

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Antigen processing: Ubiquitination & Proteasome degradation Show undefined attributes

authored	[InstanceEdit:983164] Garapati, P V, 2010-10-29
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:983164] Garapati, P V, 2010-10-29
crossReference	[DatabaseIdentifier:12819455] BioModels Database:BIOMD0000000293 [DatabaseIdentifier:12819583] BioModels Database:BIOMD0000000575 [DatabaseIdentifier:12819457] BioModels Database:BIOMD0000000220
dbId	983168
displayName	Antigen processing: Ubiquitination & Proteasome degradation
edited	[InstanceEdit:983164] Garapati, P V, 2010-10-29
eventOf	[Pathway:R-HSA-983169] Class I MHC mediated antigen processing & presentation - Homo sapiens
goBiologicalProcess	[GO_BiologicalProcess:22583] protein polyubiquitination
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-HSA-983153] E1 mediated ubiquitin activation - Homo sapiens [Reaction:R-HSA-983152] Transfer of ubiquitin from E1 to E2 - Homo sapiens [Reaction:R-HSA-983157] Interaction of E3 with substrate and E2-Ub complex - Homo sapiens [Reaction:R-HSA-983140] Transfer of Ub from E2 to substrate and release of E2 - Homo sapiens [BlackBoxEvent:R-HSA-983156] Polyubiquitination of substrate - Homo sapiens [Reaction:R-HSA-983147] Release of E3 from polyubiquitinated substrate - Homo sapiens [BlackBoxEvent:R-HSA-983150] Proteasomal cleavage of substrate - Homo sapiens [BlackBoxEvent:R-HSA-983162] Trimming of N-ter extended precursor fragments by cytosolic aminopeptidases - Homo sapiens [BlackBoxEvent:R-HSA-8940641] THOP1 cleaves oligopeptide fragment (8-16aa) - Homo sapiens
isInDisease	false
isInferred	false
lastUpdatedDate	2017-04-20
literatureReference	[LiteratureReference:982850] Antigen presentation and the ubiquitin-proteasome system in host-pathogen interactions [LiteratureReference:982980] Characterizing the specificity and cooperation of aminopeptidases in the cytosol and endoplasmic reticulum during MHC class I antigen presentation [LiteratureReference:982846] Proteasome and peptidase function in MHC-class-I-mediated antigen presentation [LiteratureReference:982871] Quantitating protein synthesis, degradation, and endogenous antigen processing [LiteratureReference:982833] The ubiquitin-proteasome proteolytic pathway: destruction for the sake of construction [LiteratureReference:982870] RING domain E3 ubiquitin ligases
maxDepth	2
modified	[InstanceEdit:12819426] Weiser, Joel, 2026-02-23
name	Antigen processing: Ubiquitination & Proteasome degradation
orthologousEvent	[Pathway:R-RNO-983168] Antigen processing: Ubiquitination & Proteasome degradation - Rattus norvegicus [Pathway:R-PFA-983168] Antigen processing: Ubiquitination & Proteasome degradation - Plasmodium falciparum [Pathway:R-SCE-983168] Antigen processing: Ubiquitination & Proteasome degradation - Saccharomyces cerevisiae [Pathway:R-SPO-983168] Antigen processing: Ubiquitination & Proteasome degradation - Schizosaccharomyces pombe [Pathway:R-DDI-983168] Antigen processing: Ubiquitination & Proteasome degradation - Dictyostelium discoideum [Pathway:R-CEL-983168] Antigen processing: Ubiquitination & Proteasome degradation - Caenorhabditis elegans [Pathway:R-DME-983168] Antigen processing: Ubiquitination & Proteasome degradation - Drosophila melanogaster [Pathway:R-GGA-983168] Antigen processing: Ubiquitination & Proteasome degradation - Gallus gallus [Pathway:R-XTR-983168] Antigen processing: Ubiquitination & Proteasome degradation - Xenopus tropicalis [Pathway:R-DRE-983168] Antigen processing: Ubiquitination & Proteasome degradation - Danio rerio [Pathway:R-SSC-983168] Antigen processing: Ubiquitination & Proteasome degradation - Sus scrofa [Pathway:R-BTA-983168] Antigen processing: Ubiquitination & Proteasome degradation - Bos taurus [Pathway:R-CFA-983168] Antigen processing: Ubiquitination & Proteasome degradation - Canis familiaris [Pathway:R-MMU-983168] Antigen processing: Ubiquitination & Proteasome degradation - Mus musculus
releaseDate	2011-06-14
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:1213482] Elliott, T, 2011-02-10
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-983168
summation	[Summation:982868] Intracellular foreign or aberrant host proteins are cleaved ...
updateTrackers	[UpdateTracker:9919365] Update Tracker - [Pathway:983168] Antigen processing: Ubiquitination & Proteasome degradation - v90:[modifyText] [UpdateTracker:9782348] Update Tracker - [Pathway:983168] Antigen processing: Ubiquitination & Proteasome degradation - v59:[updateContainedRLE] [UpdateTracker:9781630] Update Tracker - [Pathway:983168] Antigen processing: Ubiquitination & Proteasome degradation - v60:[addHasEvent] [UpdateTracker:9783507] Update Tracker - [Pathway:983168] Antigen processing: Ubiquitination & Proteasome degradation - v56:[updateContainedRLE]

Referrals

(updatedInstance)

[UpdateTracker:9919365] Update Tracker - [Pathway:983168] Antigen processing: Ubiquitination & Proteasome degradation - v90:[modifyText]
[UpdateTracker:9782348] Update Tracker - [Pathway:983168] Antigen processing: Ubiquitination & Proteasome degradation - v59:[updateContainedRLE]
[UpdateTracker:9781630] Update Tracker - [Pathway:983168] Antigen processing: Ubiquitination & Proteasome degradation - v60:[addHasEvent]
[UpdateTracker:9783507] Update Tracker - [Pathway:983168] Antigen processing: Ubiquitination & Proteasome degradation - v56:[updateContainedRLE]

(hasEvent)

[Pathway:R-HSA-983169] Class I MHC mediated antigen processing & presentation

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