Reactome | Trimming of N-ter extended precursor fragments by cytosolic aminopeptidases

Schema > BlackBoxEvent > Entries

Trimming of N-ter extended precursor fragments by cytosolic aminopeptidases Show undefined attributes

authored	[InstanceEdit:983164] Garapati, P V, 2010-10-29
catalystActivity	[CatalystActivity:983155] aminopeptidase activity of IFN gamma stimulated aminopeptidases [cytosol]
catalystActivityReference	[CatalystActivityReference:9643319] aminopeptidase activity of IFN gamma stimulated aminopeptidases [cytosol] Interferon-gamma can stimulate post-proteasomal trimming of the N terminus of an antigenic peptide by inducing leucine aminopeptidase
category	omitted
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:983151] Garapati, P V, 2010-10-29
dbId	983162
displayName	Trimming of N-ter extended precursor fragments by cytosolic aminopeptidases
edited	[InstanceEdit:983164] Garapati, P V, 2010-10-29
eventOf	[Pathway:R-HSA-983168] Antigen processing: Ubiquitination & Proteasome degradation - Homo sapiens
followingEvent	[Reaction:R-HSA-983144] Transport of Antigen peptide in to ER - Homo sapiens [BlackBoxEvent:R-HSA-8940641] THOP1 cleaves oligopeptide fragment (8-16aa) - Homo sapiens
input	[SimpleEntity:R-ALL-983036] precursor peptide fragment (>16 aa) [cytosol]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:982928] Tripeptidyl peptidase II is the major peptidase needed to trim long antigenic precursors, but is not required for most MHC class I antigen presentation [LiteratureReference:982976] Interferon-gamma can stimulate post-proteasomal trimming of the N terminus of an antigenic peptide by inducing leucine aminopeptidase [LiteratureReference:982951] Two new proteases in the MHC class I processing pathway [LiteratureReference:982859] Post-proteasomal antigen processing for major histocompatibility complex class I presentation [LiteratureReference:983431] Generation of major histocompatibility complex class I antigens: functional interplay between proteasomes and TPPII
maxDepth	1
modified	[InstanceEdit:11080360] Weiser, Joel, 2026-03-16
name	Trimming of N-ter extended precursor fragments by cytosolic aminopeptidases
orthologousEvent	[BlackBoxEvent:R-SCE-983162] Trimming of N-ter extended precursor fragments by cytosolic aminopeptidases - Saccharomyces cerevisiae [BlackBoxEvent:R-SPO-983162] Trimming of N-ter extended precursor fragments by cytosolic aminopeptidases - Schizosaccharomyces pombe [BlackBoxEvent:R-DDI-983162] Trimming of N-ter extended precursor fragments by cytosolic aminopeptidases - Dictyostelium discoideum [BlackBoxEvent:R-CEL-983162] Trimming of N-ter extended precursor fragments by cytosolic aminopeptidases - Caenorhabditis elegans [BlackBoxEvent:R-DME-983162] Trimming of N-ter extended precursor fragments by cytosolic aminopeptidases - Drosophila melanogaster [BlackBoxEvent:R-GGA-983162] Trimming of N-ter extended precursor fragments by cytosolic aminopeptidases - Gallus gallus [BlackBoxEvent:R-XTR-983162] Trimming of N-ter extended precursor fragments by cytosolic aminopeptidases - Xenopus tropicalis [BlackBoxEvent:R-DRE-983162] Trimming of N-ter extended precursor fragments by cytosolic aminopeptidases - Danio rerio [BlackBoxEvent:R-SSC-983162] Trimming of N-ter extended precursor fragments by cytosolic aminopeptidases - Sus scrofa [BlackBoxEvent:R-BTA-983162] Trimming of N-ter extended precursor fragments by cytosolic aminopeptidases - Bos taurus [BlackBoxEvent:R-CFA-983162] Trimming of N-ter extended precursor fragments by cytosolic aminopeptidases - Canis familiaris [BlackBoxEvent:R-RNO-983162] Trimming of N-ter extended precursor fragments by cytosolic aminopeptidases - Rattus norvegicus [BlackBoxEvent:R-MMU-983162] Trimming of N-ter extended precursor fragments by cytosolic aminopeptidases - Mus musculus
output	[SimpleEntity:R-ALL-8942986] L-amino acid [cytosol] [SimpleEntity:R-ALL-983032] oligopeptide fragment (8-16aa) [cytosol]
precedingEvent	[BlackBoxEvent:R-HSA-983150] Proteasomal cleavage of substrate - Homo sapiens [BlackBoxEvent:R-HSA-9912636] Proteasomal cleavage of intracellular substrate (PA28-alpha-beta-20S proteasome catalyst) - Homo sapiens [BlackBoxEvent:R-HSA-9912655] Proteasomal cleavage of intracellular substrate (immunoproteasome catalyst) - Homo sapiens [BlackBoxEvent:R-HSA-9912747] Proteasomal clevage of exogenous antigen (immunoproteasome catalyst) - Homo sapiens
releaseDate	2011-06-14
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:1213482] Elliott, T, 2011-02-10
schemaClass	BlackBoxEvent
species	[Species:48887] Homo sapiens
stId	R-HSA-983162
summation	[Summation:982877] Some peptides generated by the 26S proteasome are too long t...
updateTrackers	[UpdateTracker:9782491] Update Tracker - [BlackBoxEvent:983162] Trimming of N-ter extended precursor fragments by cytosolic aminopeptidases - v59:[add_removeOutput]

Referrals

(updatedInstance)	[UpdateTracker:9782491] Update Tracker - [BlackBoxEvent:983162] Trimming of N-ter extended precursor fragments by cytosolic aminopeptidases - v59:[add_removeOutput]
(hasEvent)	[Pathway:R-HSA-983168] Antigen processing: Ubiquitination & Proteasome degradation
(precedingEvent)	[BlackBoxEvent:R-HSA-8940641] THOP1 cleaves oligopeptide fragment (8-16aa) [Reaction:R-HSA-983144] Transport of Antigen peptide in to ER

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