Reactome | Transfer of ubiquitin from E1 to E2

Schema > Reaction > Entries

Transfer of ubiquitin from E1 to E2 Show undefined attributes

authored	[InstanceEdit:983164] Garapati, P V, 2010-10-29
catalystActivity	[CatalystActivity:983149] ubiquitin binding activity of E2 Ubiquitin-conjugating enzyme [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:983151] Garapati, P V, 2010-10-29
dbId	983152
displayName	Transfer of ubiquitin from E1 to E2
edited	[InstanceEdit:983164] Garapati, P V, 2010-10-29
eventOf	[Pathway:R-HSA-983168] Antigen processing: Ubiquitination & Proteasome degradation - Homo sapiens
followingEvent	[Reaction:R-HSA-983157] Interaction of E3 with substrate and E2-Ub complex - Homo sapiens
input	[Complex:R-HSA-976164] E1 bound ubiquitin [cytosol] [CandidateSet:R-HSA-947628] E2 Ubiquitin-conjugating enzyme [cytosol]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:976172] What was the set of ubiquitin and ubiquitin-like conjugating enzymes in the eukaryote common ancestor? [LiteratureReference:982966] The family of ubiquitin-conjugating enzymes (E2s): deciding between life and death of proteins [LiteratureReference:982937] Building ubiquitin chains: E2 enzymes at work
maxDepth	1
modified	[InstanceEdit:11108703] Weiser, Joel, 2026-03-16
name	Transfer of ubiquitin from E1 to E2
orthologousEvent	[Reaction:R-PFA-983152] Transfer of ubiquitin from E1 to E2 - Plasmodium falciparum [Reaction:R-DDI-983152] Transfer of ubiquitin from E1 to E2 - Dictyostelium discoideum [Reaction:R-CEL-983152] Transfer of ubiquitin from E1 to E2 - Caenorhabditis elegans [Reaction:R-DME-983152] Transfer of ubiquitin from E1 to E2 - Drosophila melanogaster [Reaction:R-GGA-983152] Transfer of ubiquitin from E1 to E2 - Gallus gallus [Reaction:R-XTR-983152] Transfer of ubiquitin from E1 to E2 - Xenopus tropicalis [Reaction:R-DRE-983152] Transfer of ubiquitin from E1 to E2 - Danio rerio [Reaction:R-SSC-983152] Transfer of ubiquitin from E1 to E2 - Sus scrofa [Reaction:R-BTA-983152] Transfer of ubiquitin from E1 to E2 - Bos taurus [Reaction:R-CFA-983152] Transfer of ubiquitin from E1 to E2 - Canis familiaris [Reaction:R-RNO-983152] Transfer of ubiquitin from E1 to E2 - Rattus norvegicus [Reaction:R-MMU-983152] Transfer of ubiquitin from E1 to E2 - Mus musculus
output	[CandidateSet:R-HSA-947695] Ubiquitin activating E1 enzymes [cytosol] [Complex:R-HSA-976165] Ubiquitin:E2 conjugating enzymes [cytosol]
precedingEvent	[Reaction:R-HSA-983153] E1 mediated ubiquitin activation - Homo sapiens
releaseDate	2011-06-14
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:1213482] Elliott, T, 2011-02-10
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-983152
summation	[Summation:976170] Activated ubiquitin is transferred from E1 to the active sit...

Referrals

(hasEvent)	[Pathway:R-HSA-983168] Antigen processing: Ubiquitination & Proteasome degradation
(precedingEvent)	[Reaction:R-HSA-983157] Interaction of E3 with substrate and E2-Ub complex