Reactome | Antigen processing: Ubiquitination & Proteasome degradation

Schema > Pathway > Entries

Antigen processing: Ubiquitination & Proteasome degradation Show undefined attributes

compartment	[Compartment:70101] cytosol
created	[InstanceEdit:10559787] Weiser, Joel, 2026-03-16
dbId	10649354
displayName	Antigen processing: Ubiquitination & Proteasome degradation
eventOf	[Pathway:R-DRE-983169] Class I MHC mediated antigen processing & presentation - Danio rerio
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
goBiologicalProcess	[GO_BiologicalProcess:22583] protein polyubiquitination
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-DRE-983153] E1 mediated ubiquitin activation - Danio rerio [Reaction:R-DRE-983152] Transfer of ubiquitin from E1 to E2 - Danio rerio [Reaction:R-DRE-983157] Interaction of E3 with substrate and E2-Ub complex - Danio rerio [Reaction:R-DRE-983140] Transfer of Ub from E2 to substrate and release of E2 - Danio rerio [BlackBoxEvent:R-DRE-983156] Polyubiquitination of substrate - Danio rerio [Reaction:R-DRE-983147] Release of E3 from polyubiquitinated substrate - Danio rerio [BlackBoxEvent:R-DRE-983150] Proteasomal cleavage of substrate - Danio rerio [BlackBoxEvent:R-DRE-983162] Trimming of N-ter extended precursor fragments by cytosolic aminopeptidases - Danio rerio [BlackBoxEvent:R-DRE-8940641] THOP1 cleaves oligopeptide fragment (8-16aa) - Danio rerio
inferredFrom	[Pathway:R-HSA-983168] Antigen processing: Ubiquitination & Proteasome degradation - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	2
name	Antigen processing: Ubiquitination & Proteasome degradation
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:68323] Danio rerio
stId	R-DRE-983168
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-DRE-983169] Class I MHC mediated antigen processing & presentation
(inferredTo)	[Pathway:R-HSA-983168] Antigen processing: Ubiquitination & Proteasome degradation