Reactome | Transfer of Ub from E2 to substrate and release of E2

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Transfer of Ub from E2 to substrate and release of E2 Show undefined attributes

authored	[InstanceEdit:983164] Garapati, P V, 2010-10-29
catalystActivity	[CatalystActivity:983139] ubiquitin-protein transferase activity of E3 ligases in proteasomal degradation [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:983151] Garapati, P V, 2010-10-29
dbId	983140
displayName	Transfer of Ub from E2 to substrate and release of E2
edited	[InstanceEdit:983164] Garapati, P V, 2010-10-29
eventOf	[Pathway:R-HSA-983168] Antigen processing: Ubiquitination & Proteasome degradation - Homo sapiens
followingEvent	[BlackBoxEvent:R-HSA-983156] Polyubiquitination of substrate - Homo sapiens
input	[Complex:R-HSA-983126] Ag-substrate:E3:E2:Ub [cytosol] [SimpleEntity:R-ALL-113592] ATP [cytosol]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:982919] A novel family of membrane-bound E3 ubiquitin ligases [LiteratureReference:982903] U-box proteins as a new family of ubiquitin ligases [LiteratureReference:982870] RING domain E3 ubiquitin ligases
maxDepth	1
modified	[InstanceEdit:11108703] Weiser, Joel, 2026-03-16
name	Transfer of Ub from E2 to substrate and release of E2
orthologousEvent	[Reaction:R-PFA-983140] Transfer of Ub from E2 to substrate and release of E2 - Plasmodium falciparum [Reaction:R-SCE-983140] Transfer of Ub from E2 to substrate and release of E2 - Saccharomyces cerevisiae [Reaction:R-SPO-983140] Transfer of Ub from E2 to substrate and release of E2 - Schizosaccharomyces pombe [Reaction:R-DDI-983140] Transfer of Ub from E2 to substrate and release of E2 - Dictyostelium discoideum [Reaction:R-CEL-983140] Transfer of Ub from E2 to substrate and release of E2 - Caenorhabditis elegans [Reaction:R-DME-983140] Transfer of Ub from E2 to substrate and release of E2 - Drosophila melanogaster [Reaction:R-GGA-983140] Transfer of Ub from E2 to substrate and release of E2 - Gallus gallus [Reaction:R-XTR-983140] Transfer of Ub from E2 to substrate and release of E2 - Xenopus tropicalis [Reaction:R-DRE-983140] Transfer of Ub from E2 to substrate and release of E2 - Danio rerio [Reaction:R-SSC-983140] Transfer of Ub from E2 to substrate and release of E2 - Sus scrofa [Reaction:R-BTA-983140] Transfer of Ub from E2 to substrate and release of E2 - Bos taurus [Reaction:R-CFA-983140] Transfer of Ub from E2 to substrate and release of E2 - Canis familiaris [Reaction:R-RNO-983140] Transfer of Ub from E2 to substrate and release of E2 - Rattus norvegicus [Reaction:R-MMU-983140] Transfer of Ub from E2 to substrate and release of E2 - Mus musculus
output	[SimpleEntity:R-ALL-76577] AMP [cytosol] [CandidateSet:R-HSA-947628] E2 Ubiquitin-conjugating enzyme [cytosol] [Complex:R-HSA-983131] E3:Ub:substrate [cytosol] [SimpleEntity:R-ALL-111294] PPi [cytosol]
precedingEvent	[Reaction:R-HSA-983157] Interaction of E3 with substrate and E2-Ub complex - Homo sapiens
releaseDate	2011-06-14
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:1213482] Elliott, T, 2011-02-10
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-983140
summation	[Summation:982873] Interaction of E3 with both substrate and E2-Ub, brings them...

Referrals

(hasEvent)	[Pathway:R-HSA-983168] Antigen processing: Ubiquitination & Proteasome degradation
(precedingEvent)	[BlackBoxEvent:R-HSA-983156] Polyubiquitination of substrate

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