Reactome | Polyubiquitination of substrate

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Polyubiquitination of substrate Show undefined attributes

authored	[InstanceEdit:983164] Garapati, P V, 2010-10-29
catalystActivity	[CatalystActivity:983159] ubiquitin-protein transferase activity of E3:Ub:substrate [cytosol]
catalystActivityReference	[CatalystActivityReference:9643780] ubiquitin-protein transferase activity of E3:Ub:substrate [cytosol] Maturation of human dendritic cells is accompanied by functional remodelling of the ubiquitin-proteasome system
category	omitted
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:983151] Garapati, P V, 2010-10-29
dbId	983156
displayName	Polyubiquitination of substrate
edited	[InstanceEdit:983164] Garapati, P V, 2010-10-29
eventOf	[Pathway:R-HSA-983168] Antigen processing: Ubiquitination & Proteasome degradation - Homo sapiens
followingEvent	[Reaction:R-HSA-983147] Release of E3 from polyubiquitinated substrate - Homo sapiens
input	[SimpleEntity:R-ALL-113592] ATP [cytosol] [Complex:R-HSA-983131] E3:Ub:substrate [cytosol] 2 × [Complex:R-HSA-976165] Ubiquitin:E2 conjugating enzymes [cytosol]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:982919] A novel family of membrane-bound E3 ubiquitin ligases [LiteratureReference:982903] U-box proteins as a new family of ubiquitin ligases [LiteratureReference:982870] RING domain E3 ubiquitin ligases [LiteratureReference:983291] Mechanisms of ubiquitin transfer by the anaphase-promoting complex
modified	[InstanceEdit:10931649] Wright, Adam, 2024-03-08
name	Polyubiquitination of substrate
orthologousEvent	[BlackBoxEvent:R-PFA-983156] Polyubiquitination of substrate - Plasmodium falciparum [BlackBoxEvent:R-SCE-983156] Polyubiquitination of substrate - Saccharomyces cerevisiae [BlackBoxEvent:R-SPO-983156] Polyubiquitination of substrate - Schizosaccharomyces pombe [BlackBoxEvent:R-DDI-983156] Polyubiquitination of substrate - Dictyostelium discoideum [BlackBoxEvent:R-CEL-983156] Polyubiquitination of substrate - Caenorhabditis elegans [BlackBoxEvent:R-DME-983156] Polyubiquitination of substrate - Drosophila melanogaster [BlackBoxEvent:R-GGA-983156] Polyubiquitination of substrate - Gallus gallus [BlackBoxEvent:R-XTR-983156] Polyubiquitination of substrate - Xenopus tropicalis [BlackBoxEvent:R-DRE-983156] Polyubiquitination of substrate - Danio rerio [BlackBoxEvent:R-SSC-983156] Polyubiquitination of substrate - Sus scrofa [BlackBoxEvent:R-BTA-983156] Polyubiquitination of substrate - Bos taurus [BlackBoxEvent:R-CFA-983156] Polyubiquitination of substrate - Canis familiaris [BlackBoxEvent:R-RNO-983156] Polyubiquitination of substrate - Rattus norvegicus [BlackBoxEvent:R-MMU-983156] Polyubiquitination of substrate - Mus musculus
output	[SimpleEntity:R-ALL-76577] AMP [cytosol] 2 × [CandidateSet:R-HSA-947628] E2 Ubiquitin-conjugating enzyme [cytosol] [Complex:R-HSA-983134] E3:K48-polyubiquitinated substrate [cytosol] [SimpleEntity:R-ALL-111294] PPi [cytosol]
precedingEvent	[Reaction:R-HSA-983140] Transfer of Ub from E2 to substrate and release of E2 - Homo sapiens
releaseDate	2011-06-14
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:1213482] Elliott, T, 2011-02-10
schemaClass	BlackBoxEvent
species	[Species:48887] Homo sapiens
stId	R-HSA-983156
summation	[Summation:982861] Monoubiquitinated substrate acquires additional ubiquitin mo...

Referrals

(hasEvent)	[Pathway:R-HSA-983168] Antigen processing: Ubiquitination & Proteasome degradation
(precedingEvent)	[Reaction:R-HSA-983147] Release of E3 from polyubiquitinated substrate

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