Some peptides generated by the 26S proteasome are too long to bind to MHC class I molecules. These N-terminal extended precursor peptides may be trimmed by cytosolic aminopeptidases, such as Tripeptidyl peptidase II (TPP2), puromycin-sensitive aminopeptidase (PSA), bleomycin hydrolase (BH), and leucine aminopeptidase (LAP).
Rock, KL, Beninga, J, Goldberg, AL
Zendzian, S, Rock, KL, Bhutani, N, Goldberg, AL, York, IA
Stoltze, L, Schwarz, G, Schirle, M, Stevanovic, S, Schröter, C, Hersh, LB, Rammensee, HG, Schild, H, Kalbacher, H, Thompson, MW
Kloetzel, PM
Rock, KL, Goldberg, AL, York, IA
aminopeptidase activity of IFN gamma stimulated aminopeptidases [cytosol]
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