Reactome | Trimming of N-ter extended precursor fragments by cytosolic aminopeptidases

Trimming of N-ter extended precursor fragments by cytosolic aminopeptidases

Stable Identifier

R-HSA-983162

Type

Reaction [BlackBoxEvent]

Species

Homo sapiens

Compartment

cytosol

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Trimming of N-ter extended precursor fragments by cytosolic aminopeptidases

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Some peptides generated by the 26S proteasome are too long to bind to MHC class I molecules. These N-terminal extended precursor peptides may be trimmed by cytosolic aminopeptidases, such as Tripeptidyl peptidase II (TPP2), puromycin-sensitive aminopeptidase (PSA), bleomycin hydrolase (BH), and leucine aminopeptidase (LAP).

Literature References

PubMed ID	Title	Journal	Year
9668046	Interferon-gamma can stimulate post-proteasomal trimming of the N terminus of an antigenic peptide by inducing leucine aminopeptidase Rock, KL, Beninga, J, Goldberg, AL	J Biol Chem	1998
16849449	Tripeptidyl peptidase II is the major peptidase needed to trim long antigenic precursors, but is not required for most MHC class I antigen presentation Zendzian, S, Rock, KL, Bhutani, N, Goldberg, AL, York, IA	J Immunol	2006
11062501	Two new proteases in the MHC class I processing pathway Stoltze, L, Schwarz, G, Schirle, M, Stevanovic, S, Schröter, C, Hersh, LB, Rammensee, HG, Schild, H, Kalbacher, H, Thompson, MW	Nat Immunol	2000
15224091	Generation of major histocompatibility complex class I antigens: functional interplay between proteasomes and TPPII Kloetzel, PM	Nat Immunol	2004
15224092	Post-proteasomal antigen processing for major histocompatibility complex class I presentation Rock, KL, Goldberg, AL, York, IA	Nat Immunol	2004