Reactome | Trimming of N-ter extended precursor fragments by cytosolic aminopeptidases

Trimming of N-ter extended precursor fragments by cytosolic aminopeptidases

Stable Identifier

R-HSA-983162

Type

Reaction [omitted]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

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Trimming of N-ter extended precursor fragments by cytosolic aminopeptidases

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Some peptides generated by the 26S proteasome are too long to bind to MHC class I molecules. These N-terminal extended precursor peptides may be trimmed by cytosolic aminopeptidases, such as Tripeptidyl peptidase II (TPP2), puromycin-sensitive aminopeptidase (PSA), bleomycin hydrolase (BH), and leucine aminopeptidase (LAP).

Literature References

PubMed ID	Title	Journal	Year
9668046	Interferon-gamma can stimulate post-proteasomal trimming of the N terminus of an antigenic peptide by inducing leucine aminopeptidase Beninga, J, Rock, KL, Goldberg, AL	J Biol Chem	1998
16849449	Tripeptidyl peptidase II is the major peptidase needed to trim long antigenic precursors, but is not required for most MHC class I antigen presentation York, IA, Bhutani, N, Zendzian, S, Goldberg, AL, Rock, KL	J Immunol	2006
11062501	Two new proteases in the MHC class I processing pathway Stoltze, L, Schirle, M, Schwarz, G, Schröter, C, Thompson, MW, Hersh, LB, Kalbacher, H, Stevanovic, S, Rammensee, HG, Schild, H	Nat Immunol	2000
15224091	Generation of major histocompatibility complex class I antigens: functional interplay between proteasomes and TPPII Kloetzel, PM	Nat Immunol	2004
15224092	Post-proteasomal antigen processing for major histocompatibility complex class I presentation Rock, KL, York, IA, Goldberg, AL	Nat Immunol	2004