Reactome | Transport of Antigen peptide in to ER

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Transport of Antigen peptide in to ER Show undefined attributes

authored	[InstanceEdit:983164] Garapati, P V, 2010-10-29
catalystActivity	[CatalystActivity:983154] ABC-type peptide antigen transporter activity of TAP [endoplasmic reticulum membrane]
catalystActivityReference	[CatalystActivityReference:9643445] peptide antigen-transporting ATPase activity of TAP [endoplasmic reticulum membrane] The ABC-transporter signature motif is required for peptide translocation but not peptide binding by TAP
category	transition
compartment	[Compartment:17957] endoplasmic reticulum lumen [Compartment:70101] cytosol [Compartment:12045] endoplasmic reticulum membrane
created	[InstanceEdit:983151] Garapati, P V, 2010-10-29
dbId	983144
displayName	Transport of Antigen peptide in to ER
edited	[InstanceEdit:983164] Garapati, P V, 2010-10-29
eventOf	[Pathway:R-HSA-983170] Antigen Presentation: Folding, assembly and peptide loading of class I MHC - Homo sapiens
followingEvent	[BlackBoxEvent:R-HSA-983158] Trimming of peptides in ER - Homo sapiens
input	2 × [SimpleEntity:R-ALL-113592] ATP [cytosol] [SimpleEntity:R-ALL-29356] H2O [cytosol] [SimpleEntity:R-ALL-983032] oligopeptide fragment (8-16aa) [cytosol]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:982910] The ABC-transporter signature motif is required for peptide translocation but not peptide binding by TAP [LiteratureReference:982934] Kinetic analysis of peptide binding to the TAP transport complex: evidence for structural rearrangements induced by substrate binding [LiteratureReference:982968] Antigen processing and presentation: TAPping into ABC transporters [LiteratureReference:982993] Selective and ATP-dependent translocation of peptides by the MHC-encoded transporter
maxDepth	1
modified	[InstanceEdit:11108703] Weiser, Joel, 2026-03-16
name	Transport of Antigen peptide in to ER
orthologousEvent	[Reaction:R-PFA-983144] Transport of Antigen peptide in to ER - Plasmodium falciparum [Reaction:R-SPO-983144] Transport of Antigen peptide in to ER - Schizosaccharomyces pombe [Reaction:R-DDI-983144] Transport of Antigen peptide in to ER - Dictyostelium discoideum [Reaction:R-CEL-983144] Transport of Antigen peptide in to ER - Caenorhabditis elegans [Reaction:R-DRE-983144] Transport of Antigen peptide in to ER - Danio rerio [Reaction:R-SSC-983144] Transport of Antigen peptide in to ER - Sus scrofa [Reaction:R-BTA-983144] Transport of Antigen peptide in to ER - Bos taurus [Reaction:R-RNO-983144] Transport of Antigen peptide in to ER - Rattus norvegicus [Reaction:R-MMU-983144] Transport of Antigen peptide in to ER - Mus musculus
output	2 × [SimpleEntity:R-ALL-29370] ADP [cytosol] [SimpleEntity:R-ALL-983034] oligopeptide fragment [endoplasmic reticulum lumen] 2 × [SimpleEntity:R-ALL-29372] Pi [cytosol]
precedingEvent	[BlackBoxEvent:R-HSA-983162] Trimming of N-ter extended precursor fragments by cytosolic aminopeptidases - Homo sapiens [BlackBoxEvent:R-HSA-983150] Proteasomal cleavage of substrate - Homo sapiens [BlackBoxEvent:R-HSA-9912636] Proteasomal cleavage of intracellular substrate (PA28-alpha-beta-20S proteasome catalyst) - Homo sapiens [BlackBoxEvent:R-HSA-9912655] Proteasomal cleavage of intracellular substrate (immunoproteasome catalyst) - Homo sapiens [BlackBoxEvent:R-HSA-9912747] Proteasomal clevage of exogenous antigen (immunoproteasome catalyst) - Homo sapiens
releaseDate	2011-06-14
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:1213482] Elliott, T, 2011-02-10
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-983144
summation	[Summation:982881] Transporter associated with antigen processing (TAP) is a he...
updateTrackers	[UpdateTracker:9919356] Update Tracker - [Reaction:983144] Transport of Antigen peptide in to ER - v90:[modifyText]

Referrals

(updatedInstance)	[UpdateTracker:9919356] Update Tracker - [Reaction:983144] Transport of Antigen peptide in to ER - v90:[modifyText]
(hasEvent)	[Pathway:R-HSA-983170] Antigen Presentation: Folding, assembly and peptide loading of class I MHC
(precedingEvent)	[BlackBoxEvent:R-HSA-983158] Trimming of peptides in ER

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