Reactome | Proteasomal cleavage of intracellular substrate (immunoproteasome catalyst)

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Proteasomal cleavage of intracellular substrate (immunoproteasome catalyst) Show undefined attributes

authored	[InstanceEdit:9913779] Shamovsky, Veronica, 2024-06-17
catalystActivity	[CatalystActivity:9912612] endopeptidase activity of Immunoproteasome [cytosol]
category	omitted
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:9912683] Shamovsky, Veronica, 2024-06-10
dbId	9912655
displayName	Proteasomal cleavage of intracellular substrate (immunoproteasome catalyst)
edited	[InstanceEdit:9937613] Shamovsky, Veronica, 2025-02-05
eventOf	[Pathway:R-HSA-9912633] Antigen processing: Ub, ATP-independent proteasomal degradation - Homo sapiens
followingEvent	[BlackBoxEvent:R-HSA-983162] Trimming of N-ter extended precursor fragments by cytosolic aminopeptidases - Homo sapiens [Reaction:R-HSA-983144] Transport of Antigen peptide in to ER - Homo sapiens
input	[OtherEntity:R-ALL-983035] antigenic substrate [cytosol] [SimpleEntity:R-ALL-29356] H2O [cytosol]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:9912705] Protein degradation by human 20S proteasomes elucidates the interplay between peptide hydrolysis and splicing [LiteratureReference:9912712] IFN-gamma-induced immune adaptation of the proteasome system is an accelerated and transient response [LiteratureReference:982999] 26S proteasomes and immunoproteasomes produce mainly N-extended versions of an antigenic peptide [LiteratureReference:9912682] Evaluation of Immunoproteasome-Specific Proteolytic Activity Using Fluorogenic Peptide Substrates [LiteratureReference:1236593] Role of immunoproteasomes in cross-presentation
maxDepth	1
modified	[InstanceEdit:11108703] Weiser, Joel, 2026-03-16
name	Proteasomal cleavage of intracellular substrate (immunoproteasome catalyst)
orthologousEvent	[BlackBoxEvent:R-PFA-9912655] Proteasomal cleavage of intracellular substrate (immunoproteasome catalyst) - Plasmodium falciparum [BlackBoxEvent:R-SCE-9912655] Proteasomal cleavage of intracellular substrate (immunoproteasome catalyst) - Saccharomyces cerevisiae [BlackBoxEvent:R-SPO-9912655] Proteasomal cleavage of intracellular substrate (immunoproteasome catalyst) - Schizosaccharomyces pombe [BlackBoxEvent:R-DDI-9912655] Proteasomal cleavage of intracellular substrate (immunoproteasome catalyst) - Dictyostelium discoideum [BlackBoxEvent:R-CEL-9912655] Proteasomal cleavage of intracellular substrate (immunoproteasome catalyst) - Caenorhabditis elegans [BlackBoxEvent:R-DME-9912655] Proteasomal cleavage of intracellular substrate (immunoproteasome catalyst) - Drosophila melanogaster [BlackBoxEvent:R-DRE-9912655] Proteasomal cleavage of intracellular substrate (immunoproteasome catalyst) - Danio rerio [BlackBoxEvent:R-BTA-9912655] Proteasomal cleavage of intracellular substrate (immunoproteasome catalyst) - Bos taurus [BlackBoxEvent:R-CFA-9912655] Proteasomal cleavage of intracellular substrate (immunoproteasome catalyst) - Canis familiaris [BlackBoxEvent:R-RNO-9912655] Proteasomal cleavage of intracellular substrate (immunoproteasome catalyst) - Rattus norvegicus [BlackBoxEvent:R-MMU-9912655] Proteasomal cleavage of intracellular substrate (immunoproteasome catalyst) - Mus musculus
output	[SimpleEntity:R-ALL-8955634] oligopeptide fragment (3-7aa) [cytosol] [SimpleEntity:R-ALL-983032] oligopeptide fragment (8-16aa) [cytosol] [SimpleEntity:R-ALL-983036] precursor peptide fragment (>16 aa) [cytosol]
precedingEvent	[BlackBoxEvent:R-HSA-9908186] Formation of the immunoproteasome - Homo sapiens
releaseDate	2025-03-26
reviewStatus	[ReviewStatus:9821383] three stars
schemaClass	BlackBoxEvent
species	[Species:48887] Homo sapiens
stId	R-HSA-9912655
summation	[Summation:9912701] The ubiquitin (Ub)-dependent and Ub-independent proteasomal ...

Referrals

(hasEvent)	[Pathway:R-HSA-9912633] Antigen processing: Ub, ATP-independent proteasomal degradation
(precedingEvent)	[Reaction:R-HSA-983144] Transport of Antigen peptide in to ER [BlackBoxEvent:R-HSA-983162] Trimming of N-ter extended precursor fragments by cytosolic aminopeptidases

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