Reactome | Trimming of peptides in ER

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Trimming of peptides in ER Show undefined attributes

authored	[InstanceEdit:983164] Garapati, P V, 2010-10-29
catalystActivity	[CatalystActivity:983143] endopeptidase activity of ERAP1/2 [endoplasmic reticulum lumen]
catalystActivityReference	[CatalystActivityReference:9643201] endopeptidase activity of ERAP1/2 [endoplasmic reticulum lumen] The ER aminopeptidase ERAP1 enhances or limits antigen presentation by trimming epitopes to 8-9 residues
category	omitted
compartment	[Compartment:17957] endoplasmic reticulum lumen
created	[InstanceEdit:983151] Garapati, P V, 2010-10-29
dbId	983158
displayName	Trimming of peptides in ER
edited	[InstanceEdit:983164] Garapati, P V, 2010-10-29
eventOf	[Pathway:R-HSA-983170] Antigen Presentation: Folding, assembly and peptide loading of class I MHC - Homo sapiens
followingEvent	[Reaction:R-HSA-8951499] Loading of antigenic peptides on to class I MHC - Homo sapiens
input	[SimpleEntity:R-ALL-983034] oligopeptide fragment [endoplasmic reticulum lumen]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:982896] An IFN-gamma-induced aminopeptidase in the ER, ERAP1, trims precursors to MHC class I-presented peptides [LiteratureReference:982961] The ER aminopeptidase ERAP1 enhances or limits antigen presentation by trimming epitopes to 8-9 residues [LiteratureReference:985505] ERAAP synergizes with MHC class I molecules to make the final cut in the antigenic peptide precursors in the endoplasmic reticulum
maxDepth	1
modified	[InstanceEdit:11080360] Weiser, Joel, 2026-03-16
name	Trimming of peptides in ER
orthologousEvent	[BlackBoxEvent:R-SCE-983158] Trimming of peptides in ER - Saccharomyces cerevisiae [BlackBoxEvent:R-DDI-983158] Trimming of peptides in ER - Dictyostelium discoideum [BlackBoxEvent:R-CEL-983158] Trimming of peptides in ER - Caenorhabditis elegans [BlackBoxEvent:R-DME-983158] Trimming of peptides in ER - Drosophila melanogaster [BlackBoxEvent:R-GGA-983158] Trimming of peptides in ER - Gallus gallus [BlackBoxEvent:R-XTR-983158] Trimming of peptides in ER - Xenopus tropicalis [BlackBoxEvent:R-DRE-983158] Trimming of peptides in ER - Danio rerio [BlackBoxEvent:R-SSC-983158] Trimming of peptides in ER - Sus scrofa [BlackBoxEvent:R-BTA-983158] Trimming of peptides in ER - Bos taurus [BlackBoxEvent:R-CFA-983158] Trimming of peptides in ER - Canis familiaris [BlackBoxEvent:R-RNO-983158] Trimming of peptides in ER - Rattus norvegicus [BlackBoxEvent:R-MMU-983158] Trimming of peptides in ER - Mus musculus
output	[SimpleEntity:R-ALL-983033] Antigen peptide [endoplasmic reticulum lumen] [SimpleEntity:R-ALL-8943716] L-amino acid [endoplasmic reticulum lumen]
precedingEvent	[Reaction:R-HSA-983144] Transport of Antigen peptide in to ER - Homo sapiens
releaseDate	2011-06-14
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:1213482] Elliott, T, 2011-02-10
schemaClass	BlackBoxEvent
species	[Species:48887] Homo sapiens
stId	R-HSA-983158
summation	[Summation:982842] Transporter associated with antigen processing (TAP) prefers...
updateTrackers	[UpdateTracker:9782560] Update Tracker - [BlackBoxEvent:983158] Trimming of peptides in ER - v59:[add_removeOutput]

Referrals

(updatedInstance)	[UpdateTracker:9782560] Update Tracker - [BlackBoxEvent:983158] Trimming of peptides in ER - v59:[add_removeOutput]
(hasEvent)	[Pathway:R-HSA-983170] Antigen Presentation: Folding, assembly and peptide loading of class I MHC
(precedingEvent)	[Reaction:R-HSA-8951499] Loading of antigenic peptides on to class I MHC

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