Transporter associated with antigen processing (TAP) prefers peptides 8-16 residues long, slightly longer than the canonical 8-10 residue peptides that fit into class I MHC binding sites. These longer peptides are further trimmed at their N-termini by the ER-associated aminopeptidase (ERAP). ERAP trims peptides to a length of 8-10 residues, suitable for loading into the MHC class I binding groove.
Rock, KL, Favreau, JM, Chang, SC, Keys, JA, Saric, T, Goldberg, AL, York, IA
Blanchard, N, Gonzalez, F, Shastri, N, Hammer, GE, Kanaseki, T
Tsujimoto, M, Rock, KL, Hattori, A, Markant, S, Chang, SC, Saric, T, Goldberg, AL, York, IA
endopeptidase activity of ERAP1/2 [endoplasmic reticulum lumen]
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