Transporter associated with antigen processing (TAP) prefers peptides 8-16 residues long, slightly longer than the canonical 8-10 residue peptides that fit into class I MHC binding sites. These longer peptides are further trimmed at their N-termini by the ER-associated aminopeptidase (ERAP). ERAP trims peptides to a length of 8-10 residues, suitable for loading into the MHC class I binding groove.
Kanaseki, T, Blanchard, N, Hammer, GE, Gonzalez, F, Shastri, N
York, IA, Chang, SC, Saric, T, Keys, JA, Favreau, JM, Goldberg, AL, Rock, KL
Saric, T, Chang, SC, Hattori, A, York, IA, Markant, S, Rock, KL, Tsujimoto, M, Goldberg, AL
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