Reactome | Trimming of peptides in ER

Trimming of peptides in ER

Stable Identifier

R-HSA-983158

Type

Reaction [omitted]

Species

Homo sapiens

Compartment

endoplasmic reticulum lumen

ReviewStatus

5/5

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Transporter associated with antigen processing (TAP) prefers peptides 8-16 residues long, slightly longer than the canonical 8-10 residue peptides that fit into class I MHC binding sites. These longer peptides are further trimmed at their N-termini by the ER-associated aminopeptidase (ERAP). ERAP trims peptides to a length of 8-10 residues, suitable for loading into the MHC class I binding groove.

Literature References

PubMed ID	Title	Journal	Year
12436110	The ER aminopeptidase ERAP1 enhances or limits antigen presentation by trimming epitopes to 8-9 residues York, IA, Chang, SC, Saric, T, Keys, JA, Favreau, JM, Goldberg, AL, Rock, KL	Nat Immunol	2002
17088086	ERAAP synergizes with MHC class I molecules to make the final cut in the antigenic peptide precursors in the endoplasmic reticulum Kanaseki, T, Blanchard, N, Hammer, GE, Gonzalez, F, Shastri, N	Immunity	2006
12436109	An IFN-gamma-induced aminopeptidase in the ER, ERAP1, trims precursors to MHC class I-presented peptides Saric, T, Chang, SC, Hattori, A, York, IA, Markant, S, Rock, KL, Tsujimoto, M, Goldberg, AL	Nat Immunol	2002