Transporter associated with antigen processing (TAP) prefers...

created [InstanceEdit:982858] Garapati, P V, 2010-10-29
dbId 982842
displayName Transporter associated with antigen processing (TAP) prefers...
modified [InstanceEdit:983177] Jupe, S, 2010-10-29
schemaClass Summation
text Transporter associated with antigen processing (TAP) prefers peptides 8-16 residues long, slightly longer than the canonical 8-10 residue peptides that fit into class I MHC binding sites. These longer peptides are further trimmed at their N-termini by the ER-associated aminopeptidase (ERAP). ERAP trims peptides to a length of 8-10 residues, suitable for loading into the MHC class I binding groove.
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