Reactome | Antigen Presentation: Folding, assembly and peptide loading of class I MHC

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Antigen Presentation: Folding, assembly and peptide loading of class I MHC Show undefined attributes

authored	[InstanceEdit:983164] Garapati, P V, 2010-10-29
created	[InstanceEdit:983164] Garapati, P V, 2010-10-29
dbId	983170
displayName	Antigen Presentation: Folding, assembly and peptide loading of class I MHC
edited	[InstanceEdit:983164] Garapati, P V, 2010-10-29
eventOf	[Pathway:R-HSA-983169] Class I MHC mediated antigen processing & presentation - Homo sapiens
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-HSA-983145] Binding of newly synthesized MHC class I heavy chain (HC) with calnexin - Homo sapiens [Reaction:R-HSA-983148] Interaction of Erp57 with MHC class I HC - Homo sapiens [Reaction:R-HSA-983146] Interaction of beta-2-microglobulin (B2M) chain with class I HC - Homo sapiens [Reaction:R-HSA-983142] Formation of peptide loading complex (PLC) - Homo sapiens [Reaction:R-HSA-983144] Transport of Antigen peptide in to ER - Homo sapiens [BlackBoxEvent:R-HSA-983158] Trimming of peptides in ER - Homo sapiens [Reaction:R-HSA-8951499] Loading of antigenic peptides on to class I MHC - Homo sapiens [Reaction:R-HSA-983161] Dissociation of the Antigenic peptide:MHC:B2M peptide loading complex - Homo sapiens [Reaction:R-HSA-983138] Transport of MHC heterotrimer to ER exit site - Homo sapiens [Reaction:R-HSA-203979] Coat Assembly - Homo sapiens [Reaction:R-HSA-983426] Capturing cargo and formation of prebudding complex - Homo sapiens [Reaction:R-HSA-983425] Recruitment of Sec31p:Sec13p to prebudding complex and formation of COPII vesicle - Homo sapiens [Reaction:R-HSA-983424] Budding of COPII coated vesicle - Homo sapiens [Reaction:R-HSA-983422] Disassembly of COPII coated vesicle - Homo sapiens [BlackBoxEvent:R-HSA-983421] Journey of cargo through Golgi complex - Homo sapiens [BlackBoxEvent:R-HSA-983427] Expression of peptide bound class I MHC on cell surface - Homo sapiens
isInDisease	false
isInferred	false
lastUpdatedDate	2022-04-07
literatureReference	[LiteratureReference:982853] The known unknowns of antigen processing and presentation [LiteratureReference:982859] Post-proteasomal antigen processing for major histocompatibility complex class I presentation [LiteratureReference:982839] Molecular mechanisms of MHC class I-antigen processing: redox considerations [LiteratureReference:982854] Assembly and export of MHC class I peptide ligands [LiteratureReference:982897] The quality control of MHC class I peptide loading
maxDepth	2
modified	[InstanceEdit:11108703] Weiser, Joel, 2026-03-16
name	Antigen Presentation: Folding, assembly and peptide loading of class I MHC
orthologousEvent	[Pathway:R-RNO-983170] Antigen Presentation: Folding, assembly and peptide loading of class I MHC - Rattus norvegicus [Pathway:R-PFA-983170] Antigen Presentation: Folding, assembly and peptide loading of class I MHC - Plasmodium falciparum [Pathway:R-SCE-983170] Antigen Presentation: Folding, assembly and peptide loading of class I MHC - Saccharomyces cerevisiae [Pathway:R-SPO-983170] Antigen Presentation: Folding, assembly and peptide loading of class I MHC - Schizosaccharomyces pombe [Pathway:R-DDI-983170] Antigen Presentation: Folding, assembly and peptide loading of class I MHC - Dictyostelium discoideum [Pathway:R-CEL-983170] Antigen Presentation: Folding, assembly and peptide loading of class I MHC - Caenorhabditis elegans [Pathway:R-DME-983170] Antigen Presentation: Folding, assembly and peptide loading of class I MHC - Drosophila melanogaster [Pathway:R-GGA-983170] Antigen Presentation: Folding, assembly and peptide loading of class I MHC - Gallus gallus [Pathway:R-XTR-983170] Antigen Presentation: Folding, assembly and peptide loading of class I MHC - Xenopus tropicalis [Pathway:R-DRE-983170] Antigen Presentation: Folding, assembly and peptide loading of class I MHC - Danio rerio [Pathway:R-SSC-983170] Antigen Presentation: Folding, assembly and peptide loading of class I MHC - Sus scrofa [Pathway:R-BTA-983170] Antigen Presentation: Folding, assembly and peptide loading of class I MHC - Bos taurus [Pathway:R-CFA-983170] Antigen Presentation: Folding, assembly and peptide loading of class I MHC - Canis familiaris [Pathway:R-MMU-983170] Antigen Presentation: Folding, assembly and peptide loading of class I MHC - Mus musculus
releaseDate	2011-06-14
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:1213482] Elliott, T, 2011-02-10
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-983170
summation	[Summation:982864] Unlike other glycoproteins, correct folding of MHC class I m...
updateTrackers	[UpdateTracker:9775046] Update Tracker - [Pathway:983170] Antigen Presentation: Folding, assembly and peptide loading of class I MHC - v80:[updateContainedRLE] [UpdateTracker:9782499] Update Tracker - [Pathway:983170] Antigen Presentation: Folding, assembly and peptide loading of class I MHC - v59:[updateContainedRLE] [UpdateTracker:9781621] Update Tracker - [Pathway:983170] Antigen Presentation: Folding, assembly and peptide loading of class I MHC - v60:[addHasEvent, updateContainedRLE] [UpdateTracker:9784311] Update Tracker - [Pathway:983170] Antigen Presentation: Folding, assembly and peptide loading of class I MHC - v54:[addHasEvent, updateContainedRLE] [UpdateTracker:9777844] Update Tracker - [Pathway:983170] Antigen Presentation: Folding, assembly and peptide loading of class I MHC - v68:[updateContainedRLE]

Referrals

(updatedInstance)

[UpdateTracker:9775046] Update Tracker - [Pathway:983170] Antigen Presentation: Folding, assembly and peptide loading of class I MHC - v80:[updateContainedRLE]
[UpdateTracker:9782499] Update Tracker - [Pathway:983170] Antigen Presentation: Folding, assembly and peptide loading of class I MHC - v59:[updateContainedRLE]
[UpdateTracker:9781621] Update Tracker - [Pathway:983170] Antigen Presentation: Folding, assembly and peptide loading of class I MHC - v60:[addHasEvent, updateContainedRLE]
[UpdateTracker:9784311] Update Tracker - [Pathway:983170] Antigen Presentation: Folding, assembly and peptide loading of class I MHC - v54:[addHasEvent, updateContainedRLE]
[UpdateTracker:9777844] Update Tracker - [Pathway:983170] Antigen Presentation: Folding, assembly and peptide loading of class I MHC - v68:[updateContainedRLE]

(hasEvent)

[Pathway:R-HSA-983169] Class I MHC mediated antigen processing & presentation

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