Reactome | Spliceosomal B* complex [nucleoplasm]

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Spliceosomal B* complex [nucleoplasm] Show undefined attributes

catalystActivities	[CatalystActivity:9794535] first spliceosomal transesterification activity of Spliceosomal B* complex [nucleoplasm]
compartment	[Compartment:7660] nucleoplasm
consumedByEvent	[BlackBoxEvent:R-HSA-9794542] Formation of the Spliceosomal C complex containing intron lariat - Homo sapiens
created	[InstanceEdit:9794540] May, Bruce, 2022-07-13
dbId	9794539
displayName	Spliceosomal B* complex [nucleoplasm]
hasComponent	[EntityWithAccessionedSequence:R-HSA-156649] ALYREF [nucleoplasm] [DefinedSet:R-HSA-9770781] ASAP complex, PSAP complex [nucleoplasm] [Complex:R-HSA-9970414] capped, methylated, polyadenylated pre-mRNP:CBC complex [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-9769561] CCDC12 [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-72062] CDC40 [nucleoplasm] [Complex:R-HSA-8849113] Core EJC [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-8865956] CWC22 [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-8867898] CWC25 [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-8849139] DDX39B [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-3900136] DDX5 [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-9770427] DHX35 [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-72060] DHX38 [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-9770419] GPATCH1 [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-9770428] NSRP1 [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-9769592] PPIG [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-8867892] PPIL1 [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-9769562] PPIL2 [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-8952110] PPIL3 [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-8952113] PPIL4 [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-8867893] PPWD1 [nucleoplasm] [Complex:R-HSA-5420896] PRP19-CDC5L complex [nucleoplasm] [Complex:R-HSA-9769565] PRP19-CDC5L related complex [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-6791189] SKIV2L2 [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-156781] SRRM1 [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-8865888] SRRM2 [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-6814858] SRRT [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-8867884] SYF2 [nucleoplasm] [Complex:R-HSA-8869309] U2 12S snRNP [nucleoplasm] [Complex:R-HSA-9769567] U5 snRNP (no DDX23,PRPF6,TXNL4A) [nucleoplasm] [Complex:R-HSA-9794541] U6 snRNA:2Mg2+ [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-156776] UPF3B [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-9770425] WDR70 [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-9770430] YJU2 [nucleoplasm]
inDisease	false
inferredTo	[Complex:R-MMU-9794539] Spliceosomal B* complex [nucleoplasm] - Mus musculus [Complex:R-RNO-9794539] Spliceosomal B* complex [nucleoplasm] - Rattus norvegicus [Complex:R-CFA-9794539] Spliceosomal B* complex [nucleoplasm] - Canis familiaris [Complex:R-BTA-9794539] Spliceosomal B* complex [nucleoplasm] - Bos taurus [Complex:R-SSC-9794539] Spliceosomal B* complex [nucleoplasm] - Sus scrofa [Complex:R-DRE-9794539] Spliceosomal B* complex [nucleoplasm] - Danio rerio [Complex:R-XTR-9794539] Spliceosomal B* complex [nucleoplasm] - Xenopus tropicalis [Complex:R-GGA-9794539] Spliceosomal B* complex [nucleoplasm] - Gallus gallus [Complex:R-DME-9794539] Spliceosomal B* complex [nucleoplasm] - Drosophila melanogaster [Complex:R-CEL-9794539] Spliceosomal B* complex [nucleoplasm] - Caenorhabditis elegans [Complex:R-DDI-9794539] Spliceosomal B* complex [nucleoplasm] - Dictyostelium discoideum [Complex:R-SPO-9794539] Spliceosomal B* complex [nucleoplasm] - Schizosaccharomyces pombe [Complex:R-PFA-9794539] Spliceosomal B* complex [nucleoplasm] - Plasmodium falciparum
literatureReference	[LiteratureReference:9769583] Structural Insights into Nuclear pre-mRNA Splicing in Higher Eukaryotes [LiteratureReference:9770575] Tri-snRNP-associated proteins interact with subunits of the TRAMP and nuclear exosome complexes, linking RNA decay and pre-mRNA splicing [LiteratureReference:157383] 5' exon interactions within the human spliceosome establish a framework for exon junction complex structure and assembly [LiteratureReference:6806809] Characterization of purified human Bact spliceosomal complexes reveals compositional and morphological changes during spliceosome activation and first step catalysis [LiteratureReference:9770574] Mass spectrometry-based relative quantification of proteins in precatalytic and catalytically active spliceosomes by metabolic labeling (SILAC), chemical labeling (iTRAQ), and label-free spectral count [LiteratureReference:9770594] Semiquantitative proteomic analysis of the human spliceosome via a novel two-dimensional gel electrophoresis method [LiteratureReference:5566504] Small nuclear ribonucleoprotein remodeling during catalytic activation of the spliceosome [LiteratureReference:72132] Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis. [LiteratureReference:927736] A simple whole cell lysate system for in vitro splicing reveals a stepwise assembly of the exon-exon junction complex [LiteratureReference:9772613] Structure of a human catalytic step I spliceosome
maxDepth	6
modified	[InstanceEdit:9971062] Orlic-Milacic, Marija, 2025-11-04
name	Spliceosomal B* complex
producedByEvent	[BlackBoxEvent:R-HSA-9770131] Formation of the Spliceosomal B* complex - Homo sapiens
schemaClass	Complex
species	[Species:48887] Homo sapiens
stId	R-HSA-9794539
updateTrackers	[UpdateTracker:9928564] Update Tracker - [Complex:9794539] Spliceosomal B* complex [nucleoplasm] - v91:[addHasComponent] [UpdateTracker:9972367] Update Tracker - [Complex:9794539] Spliceosomal B* complex [nucleoplasm] - v95:[add_removeHasComponent]

Referrals

(input)	[BlackBoxEvent:R-HSA-9794542] Formation of the Spliceosomal C complex containing intron lariat
(output)	[BlackBoxEvent:R-HSA-9770131] Formation of the Spliceosomal B* complex
(physicalEntity)	[CatalystActivity:9794535] first spliceosomal transesterification activity of Spliceosomal B* complex [nucleoplasm]
(updatedInstance)	[UpdateTracker:9928564] Update Tracker - [Complex:9794539] Spliceosomal B* complex [nucleoplasm] - v91:[addHasComponent] [UpdateTracker:9972367] Update Tracker - [Complex:9794539] Spliceosomal B* complex [nucleoplasm] - v95:[add_removeHasComponent]

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