Reactome | Prednisone ADME

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Prednisone ADME Show undefined attributes

authored	[InstanceEdit:9757127] Stephan, Ralf, 2021-10-27
compartment	[Compartment:70101] cytosol [Compartment:984] extracellular region
created	[InstanceEdit:9757109] Shamovsky, Veronica, 2021-10-27
crossReference	[DatabaseIdentifier:9795008] PharmGKB:PA166273601
dbId	9757110
displayName	Prednisone ADME
doi	10.3180/R-HSA-9757110.1
edited	[InstanceEdit:9767896] Stephan, Ralf, 2022-03-02
eventOf	[TopLevelPathway:R-HSA-9748784] Drug ADME - Homo sapiens
hasDiagram	true
hasEHLD	false
hasEvent	[BlackBoxEvent:R-HSA-9757540] PREDN,PREDL diffuse into GI cells - Homo sapiens [Reaction:R-HSA-9659680] ABCB1 transports xenobiotics out of the cell - Homo sapiens [Reaction:R-HSA-9757578] ALB binds PREDN - Homo sapiens [Reaction:R-HSA-9757574] ALB binds PREDL - Homo sapiens [Reaction:R-HSA-9762345] PREDN:ALB dissociates - Homo sapiens [Reaction:R-HSA-9762343] PREDL:ALB dissociates - Homo sapiens [Reaction:R-HSA-9757688] SERPINA6 binds PREDN - Homo sapiens [Reaction:R-HSA-9757686] SERPINA6 binds PREDL - Homo sapiens [BlackBoxEvent:R-HSA-9757698] PREDN,PREDL diffuse into hepatic cells - Homo sapiens [Reaction:R-HSA-9757706] HSD11B1 hydrogenates PREDN to PREDL in hepatic cell - Homo sapiens [Reaction:R-HSA-9759461] ABCB1 transports PREDN,PREDL out of hepatic cells - Homo sapiens [BlackBoxEvent:R-HSA-9759445] PREDN,PREDL diffuse into kidney cells - Homo sapiens [Reaction:R-HSA-9759259] HSD11B2 dehydrogenates PREDL to PREDN - Homo sapiens [Reaction:R-HSA-9759454] ABCB1 transports PREDN,PREDL out of kidney cells - Homo sapiens [Reaction:R-HSA-9758674] CYP3A4 oxidizes PREDN,PREDL - Homo sapiens [Reaction:R-HSA-9758682] AKR1C1 hydrogenates PREDN,PREDL - Homo sapiens [Reaction:R-HSA-9758661] UGT2B7,2B17,1A3 glucuronidates PRED metabolites - Homo sapiens [BlackBoxEvent:R-HSA-9758868] Unknown efflux pump transports glucuronidated PRED metabolite - Homo sapiens
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:9757115] Biowaiver monographs for immediate release solid oral dosage forms: prednisone [LiteratureReference:9757114] Clinical pharmacokinetics of prednisone and prednisolone [LiteratureReference:9757132] Urinary excretion profile of prednisone and prednisolone after different administration routes [LiteratureReference:9759613] Detection and characterization of prednisolone metabolites in human urine by LC-MS/MS [LiteratureReference:9757699] 11 beta-hydroxysteroid dehydrogenase is an exclusive 11 beta- reductase in primary cultures of rat hepatocytes: effect of physicochemical and hormonal manipulations [LiteratureReference:9757704] 11beta-hydroxysteroid dehydrogenase types 1 and 2: an important pharmacokinetic determinant for the activity of synthetic mineralo- and glucocorticoids [LiteratureReference:9759261] Immunohistochemical localization of type 1 11beta-hydroxysteroid dehydrogenase in human tissues
maxDepth	2
modified	[InstanceEdit:11108703] Weiser, Joel, 2026-03-16
name	Prednisone ADME
orthologousEvent	[Pathway:R-MMU-9757110] Prednisone ADME - Mus musculus [Pathway:R-RNO-9757110] Prednisone ADME - Rattus norvegicus [Pathway:R-CFA-9757110] Prednisone ADME - Canis familiaris [Pathway:R-BTA-9757110] Prednisone ADME - Bos taurus [Pathway:R-SSC-9757110] Prednisone ADME - Sus scrofa [Pathway:R-DRE-9757110] Prednisone ADME - Danio rerio [Pathway:R-XTR-9757110] Prednisone ADME - Xenopus tropicalis [Pathway:R-GGA-9757110] Prednisone ADME - Gallus gallus [Pathway:R-DME-9757110] Prednisone ADME - Drosophila melanogaster [Pathway:R-CEL-9757110] Prednisone ADME - Caenorhabditis elegans [Pathway:R-DDI-9757110] Prednisone ADME - Dictyostelium discoideum [Pathway:R-SPO-9757110] Prednisone ADME - Schizosaccharomyces pombe [Pathway:R-SCE-9757110] Prednisone ADME - Saccharomyces cerevisiae [Pathway:R-PFA-9757110] Prednisone ADME - Plasmodium falciparum
previousReviewStatus	[ReviewStatus:9821385] four stars
releaseDate	2022-09-14
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9796130] Thorn, Caroline F, 2022-08-05 [InstanceEdit:9919316] D'Eustachio, Peter, 2024-08-21
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-9757110
summation	[Summation:9757111] Prednisone (PREDN) is a prodrug of prednisolone (PREDL), and...

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[TopLevelPathway:R-HSA-9748784] Drug ADME

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