Reactome | Prednisone ADME

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Prednisone ADME Show undefined attributes

compartment	[Compartment:70101] cytosol [Compartment:984] extracellular region
created	[InstanceEdit:10102717] Weiser, Joel, 2026-03-16
dbId	10225329
displayName	Prednisone ADME
eventOf	[TopLevelPathway:R-RNO-9748784] Drug ADME - Rattus norvegicus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
hasDiagram	true
hasEHLD	false
hasEvent	[Reaction:R-RNO-9659680] ABCB1 transports xenobiotics out of the cell - Rattus norvegicus [Reaction:R-RNO-9757578] ALB binds PREDN - Rattus norvegicus [Reaction:R-RNO-9757574] ALB binds PREDL - Rattus norvegicus [Reaction:R-RNO-9762345] PREDN:ALB dissociates - Rattus norvegicus [Reaction:R-RNO-9762343] PREDL:ALB dissociates - Rattus norvegicus [Reaction:R-RNO-9757688] SERPINA6 binds PREDN - Rattus norvegicus [Reaction:R-RNO-9757686] SERPINA6 binds PREDL - Rattus norvegicus [Reaction:R-RNO-9757706] HSD11B1 hydrogenates PREDN to PREDL in hepatic cell - Rattus norvegicus [Reaction:R-RNO-9759461] ABCB1 transports PREDN,PREDL out of hepatic cells - Rattus norvegicus [Reaction:R-RNO-9759259] HSD11B2 dehydrogenates PREDL to PREDN - Rattus norvegicus [Reaction:R-RNO-9759454] ABCB1 transports PREDN,PREDL out of kidney cells - Rattus norvegicus [Reaction:R-RNO-9758674] CYP3A4 oxidizes PREDN,PREDL - Rattus norvegicus [Reaction:R-RNO-9758682] AKR1C1 hydrogenates PREDN,PREDL - Rattus norvegicus [Reaction:R-RNO-9758661] UGT2B7,2B17,1A3 glucuronidates PRED metabolites - Rattus norvegicus
inferredFrom	[Pathway:R-HSA-9757110] Prednisone ADME - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	2
name	Prednisone ADME
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:48895] Rattus norvegicus
stId	R-RNO-9757110
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[TopLevelPathway:R-RNO-9748784] Drug ADME
(inferredTo)	[Pathway:R-HSA-9757110] Prednisone ADME

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