Reactome | ABCB1 transports xenobiotics out of the cell

Schema > Reaction > Entries

ABCB1 transports xenobiotics out of the cell Show undefined attributes

authored	[InstanceEdit:9757127] Stephan, Ralf, 2021-10-27
catalystActivity	[CatalystActivity:2161511] ATPase-coupled transmembrane transporter activity of ABCB1 [plasma membrane]
category	transition
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol [Compartment:984] extracellular region
created	[InstanceEdit:9659679] Orlic-Milacic, Marija, 2019-09-04
dbId	9659680
displayName	ABCB1 transports xenobiotics out of the cell
edited	[InstanceEdit:9767896] Stephan, Ralf, 2022-03-02
eventOf	[Pathway:R-HSA-9757110] Prednisone ADME - Homo sapiens
followingEvent	[Reaction:R-HSA-9757578] ALB binds PREDN - Homo sapiens [Reaction:R-HSA-9757574] ALB binds PREDL - Homo sapiens [Reaction:R-HSA-9757688] SERPINA6 binds PREDN - Homo sapiens [Reaction:R-HSA-9757686] SERPINA6 binds PREDL - Homo sapiens [BlackBoxEvent:R-HSA-9757698] PREDN,PREDL diffuse into hepatic cells - Homo sapiens [BlackBoxEvent:R-HSA-9759445] PREDN,PREDL diffuse into kidney cells - Homo sapiens
input	[SimpleEntity:R-ALL-113592] ATP [cytosol] [SimpleEntity:R-ALL-29356] H2O [cytosol] [DefinedSet:R-ALL-9659678] xenobiotics (ABCB1) [cytosol]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:9659837] Partial purification and reconstitution of the human multidrug-resistance pump: characterization of the drug-stimulatable ATP hydrolysis [LiteratureReference:9659871] Retroviral transfer of the human MDR1 gene confers resistance to bisantrene-specific hematotoxicity [LiteratureReference:9659888] P-glycoprotein mediates profound resistance to bisantrene [LiteratureReference:9659886] Expression of a full-length cDNA for the human "MDR1" gene confers resistance to colchicine, doxorubicin, and vinblastine [LiteratureReference:9659907] Transepithelial transport of drugs by the multidrug transporter in cultured Madin-Darby canine kidney cell epithelia [LiteratureReference:9659900] Interaction of docetaxel ("Taxotere") with human P-glycoprotein [LiteratureReference:9659930] A retrovirus carrying an MDR1 cDNA confers multidrug resistance and polarized expression of P-glycoprotein in MDCK cells [LiteratureReference:9659916] Multidrug resistance phenotype of human BRO melanoma cells transfected with a wild-type human mdr1 complementary DNA [LiteratureReference:9659932] Inhibition of MDR1 expression by retinol treatment increases sensitivity to etoposide (VP16) in human neoplasic cell line [LiteratureReference:9659938] Distribution of STI-571 to the brain is limited by P-glycoprotein-mediated efflux [LiteratureReference:9659944] Kinetics of P-glycoprotein-mediated efflux of paclitaxel [LiteratureReference:9659947] P-glycoprotein but not topoisomerase II and glutathione-S-transferase-pi accounts for enhanced intracellular drug-resistance in LoVo MDR human cell lines [LiteratureReference:9659959] Efficient inhibition of P-glycoprotein-mediated multidrug resistance with a monoclonal antibody [LiteratureReference:9660713] Influx and efflux transport as determinants of melphalan cytotoxicity: Resistance to melphalan in MDR1 overexpressing tumor cell lines [LiteratureReference:9660730] Temozolomide competes for P-glycoprotein and contributes to chemoresistance in glioblastoma cells [LiteratureReference:9660758] P-glycoprotein, but not multidrug resistance protein 4, plays a role in the systemic clearance of irinotecan and SN-38 in mice [LiteratureReference:9660747] MDR1 polymorphism role in patients treated with cetuximab and irinotecan in irinotecan refractory colorectal cancer [LiteratureReference:9660779] Identification of budesonide and prednisone as substrates of the intestinal drug efflux pump P-glycoprotein [LiteratureReference:9660949] Structural determinants of P-glycoprotein-mediated transport of glucocorticoids [LiteratureReference:9660964] Polymorphisms in the multidrug-resistance 1 gene related to glucocorticoid response in rheumatoid arthritis treatment [LiteratureReference:9660934] The role of the efflux transporter P-glycoprotein in brain penetration of prednisolone [LiteratureReference:9660948] Profound differences in the transport of steroids by two mouse P-glycoproteins [LiteratureReference:9660941] Pharmacokinetics of erythromycin in rabbit corneas after single-dose infusion: role of P-glycoprotein as a barrier to in vivo ocular drug absorption [LiteratureReference:9660947] Differences in assessment of macrolide interaction with human MDR1 (ABCB1, P-gp) using rhodamine-123 efflux, ATPase activity and cellular accumulation assays [LiteratureReference:9661286] Characterisation of the roles of ABCB1, ABCC1, ABCC2 and ABCG2 in the transport and pharmacokinetics of actinomycin D in vitro and in vivo [LiteratureReference:9659662] Multidrug resistance in cancer: role of ATP-dependent transporters [LiteratureReference:9770936] Is the emperor wearing shorts? The published structures of ABC transporters [LiteratureReference:9770935] Stoichiometry of coupling of rhodamine 123 transport to ATP hydrolysis by P-glycoprotein [LiteratureReference:9795015] Molecular pathways: regulation and therapeutic implications of multidrug resistance [LiteratureReference:9795018] Internal duplication and homology with bacterial transport proteins in the mdr1 (P-glycoprotein) gene from multidrug-resistant human cells [LiteratureReference:9753594] Membrane transporters in drug development [LiteratureReference:9916942] Intestinal drug transporters: an overview
maxDepth	1
modified	[InstanceEdit:11108703] Weiser, Joel, 2026-03-16
name	ABCB1 transports xenobiotics out of the cell
orthologousEvent	[Reaction:R-PFA-9659680] ABCB1 transports xenobiotics out of the cell - Plasmodium falciparum [Reaction:R-SPO-9659680] ABCB1 transports xenobiotics out of the cell - Schizosaccharomyces pombe [Reaction:R-DDI-9659680] ABCB1 transports xenobiotics out of the cell - Dictyostelium discoideum [Reaction:R-GGA-9659680] ABCB1 transports xenobiotics out of the cell - Gallus gallus [Reaction:R-DRE-9659680] ABCB1 transports xenobiotics out of the cell - Danio rerio [Reaction:R-SSC-9659680] ABCB1 transports xenobiotics out of the cell - Sus scrofa [Reaction:R-BTA-9659680] ABCB1 transports xenobiotics out of the cell - Bos taurus [Reaction:R-MMU-9659680] ABCB1 transports xenobiotics out of the cell - Mus musculus [Reaction:R-RNO-9659680] ABCB1 transports xenobiotics out of the cell - Rattus norvegicus [Reaction:R-CFA-9659680] ABCB1 transports xenobiotics out of the cell - Canis familiaris
output	[SimpleEntity:R-ALL-29370] ADP [cytosol] [SimpleEntity:R-ALL-29372] Pi [cytosol] [DefinedSet:R-ALL-9659675] xenobiotics (ABCB1) [extracellular region]
precedingEvent	[BlackBoxEvent:R-HSA-9757540] PREDN,PREDL diffuse into GI cells - Homo sapiens
regulatedBy	[NegativeRegulation:9659970] Negative regulation by 'ABCB1:ABCB1 inhibitors [plasma membrane]'
releaseDate	2022-09-14
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9796130] Thorn, Caroline F, 2022-08-05
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9659680
summation	[Summation:9659772] The ATP-dependent translocase ABCB1 (also known as Multidrug...
updateTrackers	[UpdateTracker:9919460] Update Tracker - [Reaction:9659680] ABCB1 transports xenobiotics out of the cell - v90:[modifyText, removeLiteratureReference]

Referrals

(precedingEvent)	[Reaction:R-HSA-9757578] ALB binds PREDN [Reaction:R-HSA-9757574] ALB binds PREDL [Reaction:R-HSA-9757688] SERPINA6 binds PREDN [Reaction:R-HSA-9757686] SERPINA6 binds PREDL [BlackBoxEvent:R-HSA-9757698] PREDN,PREDL diffuse into hepatic cells [BlackBoxEvent:R-HSA-9759445] PREDN,PREDL diffuse into kidney cells
(hasEvent)	[Pathway:R-HSA-9757110] Prednisone ADME
(updatedInstance)	[UpdateTracker:9919460] Update Tracker - [Reaction:9659680] ABCB1 transports xenobiotics out of the cell - v90:[modifyText, removeLiteratureReference]

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