Reactome | HSD11B2 dehydrogenates PREDL to PREDN

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HSD11B2 dehydrogenates PREDL to PREDN Show undefined attributes

authored	[InstanceEdit:9759263] Stephan, Ralf, 2021-12-02
catalystActivity	[CatalystActivity:9759257] 11-beta-hydroxysteroid dehydrogenase (NADP+) activity of HSD11B2 dimer [endoplasmic reticulum membrane]
category	transition
compartment	[Compartment:70101] cytosol [Compartment:12045] endoplasmic reticulum membrane
created	[InstanceEdit:9759264] Stephan, Ralf, 2021-12-02
crossReference	[DatabaseIdentifier:9770669] RHEA:11389
dbId	9759259
displayName	HSD11B2 dehydrogenates PREDL to PREDN
edited	[InstanceEdit:9767896] Stephan, Ralf, 2022-03-02
eventOf	[Pathway:R-HSA-9757110] Prednisone ADME - Homo sapiens
followingEvent	[Reaction:R-HSA-9759454] ABCB1 transports PREDN,PREDL out of kidney cells - Homo sapiens
input	[SimpleEntity:R-ALL-29366] NADP+ [cytosol] [ChemicalDrug:R-ALL-9759447] PREDL (kidney cell) [cytosol]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:9757699] 11 beta-hydroxysteroid dehydrogenase is an exclusive 11 beta- reductase in primary cultures of rat hepatocytes: effect of physicochemical and hormonal manipulations [LiteratureReference:9757704] 11beta-hydroxysteroid dehydrogenase types 1 and 2: an important pharmacokinetic determinant for the activity of synthetic mineralo- and glucocorticoids [LiteratureReference:9759261] Immunohistochemical localization of type 1 11beta-hydroxysteroid dehydrogenase in human tissues
maxDepth	1
modified	[InstanceEdit:11051501] Weiser, Joel, 2026-03-16
name	HSD11B2 dehydrogenates PREDL to PREDN
negativePrecedingEvent	[NegativePrecedingEvent:9761233] Different Cell Type: AKR1C1 hydrogenates PREDN,PREDL [NegativePrecedingEvent:9761234] Different Cell Type: HSD11B1 hydrogenates PREDN to PREDL in hepatic cell
orthologousEvent	[Reaction:R-DME-9759259] HSD11B2 dehydrogenates PREDL to PREDN - Drosophila melanogaster [Reaction:R-XTR-9759259] HSD11B2 dehydrogenates PREDL to PREDN - Xenopus tropicalis [Reaction:R-SPO-9759259] HSD11B2 dehydrogenates PREDL to PREDN - Schizosaccharomyces pombe [Reaction:R-GGA-9759259] HSD11B2 dehydrogenates PREDL to PREDN - Gallus gallus [Reaction:R-DRE-9759259] HSD11B2 dehydrogenates PREDL to PREDN - Danio rerio [Reaction:R-SSC-9759259] HSD11B2 dehydrogenates PREDL to PREDN - Sus scrofa [Reaction:R-BTA-9759259] HSD11B2 dehydrogenates PREDL to PREDN - Bos taurus [Reaction:R-CFA-9759259] HSD11B2 dehydrogenates PREDL to PREDN - Canis familiaris [Reaction:R-RNO-9759259] HSD11B2 dehydrogenates PREDL to PREDN - Rattus norvegicus [Reaction:R-MMU-9759259] HSD11B2 dehydrogenates PREDL to PREDN - Mus musculus
output	[SimpleEntity:R-ALL-70106] H+ [cytosol] [SimpleEntity:R-ALL-29364] NADPH [cytosol] [ChemicalDrug:R-ALL-9759446] PREDN (kidney cell) [cytosol]
precedingEvent	[BlackBoxEvent:R-HSA-9759445] PREDN,PREDL diffuse into kidney cells - Homo sapiens
releaseDate	2022-09-14
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9796130] Thorn, Caroline F, 2022-08-05
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9759259
summation	[Summation:9759260] Prednisolone (PREDL) is dehydrogenated to prednisone (PREDN)...

Referrals

(hasEvent)	[Pathway:R-HSA-9757110] Prednisone ADME
(precedingEvent)	[NegativePrecedingEvent:9761232] Different Cell Type: HSD11B2 dehydrogenates PREDL to PREDN [NegativePrecedingEvent:9761237] Different Cell Type: HSD11B2 dehydrogenates PREDL to PREDN [Reaction:R-HSA-9759454] ABCB1 transports PREDN,PREDL out of kidney cells

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