TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation

Stable Identifier
R-HSA-975138
Type
Pathway
Species
Homo sapiens
Related Species
Human immunodeficiency virus 1, Influenza A virus, Human SARS coronavirus, Severe acute respiratory syndrome coronavirus 2
Compartment
cytosol, endosome membrane, nucleoplasm
ReviewStatus
5/5
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TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
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TRAF6 mediates NFkB activation via canonical phosphorylation of IKK complex by TAK1. TRAF6 and TAK1 also regulate MAPK cascades leading to the activation of AP-1.

Literature References
PubMed ID Title Journal Year
22511786 Essential role for IKK? in production of type 1 interferons by plasmacytoid dendritic cells

Shpiro, N, Pauls, E, Sorcek, RJ, Cohen, P, Peggie, M, Young, ER, Choi, HG, Tan, L

J. Biol. Chem. 2012
18794297 The kinase activity of IL-1 receptor-associated kinase 4 is required for interleukin-1 receptor/toll-like receptor-induced TAK1-dependent NFkappaB activation

Kim, TW, Li, X, Wen, Q, Li, Y, Xiao, H, Yao, J, Casanova, JL, Fraczek, J, Pryjma, J

J. Biol. Chem. 2008
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Orthologous Events
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Bos taurus)
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Caenorhabditis elegans)
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Canis familiaris)
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Danio rerio)
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Dictyostelium discoideum)
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Drosophila melanogaster)
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Gallus gallus)
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Mus musculus)
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Plasmodium falciparum)
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Rattus norvegicus)
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Saccharomyces cerevisiae)
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Schizosaccharomyces pombe)
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Sus scrofa)
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Xenopus tropicalis)
Cross References
BioModels Database
Authored
Shamovsky, V  (2010-08-25)
Reviewed
Gillespie, ME  (2010-10-29)
Created
Shamovsky, V  (2010-09-22)
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