Reactome | TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation

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TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation Show undefined attributes

compartment	[Compartment:70101] cytosol [Compartment:74700] endosome membrane [Compartment:7660] nucleoplasm
created	[InstanceEdit:10447035] Weiser, Joel, 2026-03-16
dbId	10556451
displayName	TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
eventOf	[Pathway:R-SSC-975155] MyD88 dependent cascade initiated on endosome - Sus scrofa
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
hasDiagram	false
hasEHLD	false
hasEvent	[Pathway:R-SSC-975144] IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation - Sus scrofa [Pathway:R-SSC-975163] IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation - Sus scrofa [Pathway:R-SSC-445989] TAK1-dependent IKK and NF-kappa-B activation - Sus scrofa [Reaction:R-SSC-166869] TRAF6 binds MEKK1 - Sus scrofa [Pathway:R-SSC-450294] MAP kinase activation - Sus scrofa
inferredFrom	[Pathway:R-HSA-975138] TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	6
name	TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:49633] Sus scrofa
stId	R-SSC-975138
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-SSC-975155] MyD88 dependent cascade initiated on endosome
(inferredTo)	[Pathway:R-HSA-975138] TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation

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