TRAF6 ubiquitinqtes IRF7 within the activated TLR7/8 or 9 complex

Stable Identifier
Reaction [omitted]
Homo sapiens
Related Species
Human immunodeficiency virus 1, Influenza A virus, Human SARS coronavirus, Severe acute respiratory syndrome coronavirus 2
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TRAF6 E3 ubiquitin ligase activity was shown to be essential for IRF7 activation, although the role of TRAF6-dependent ubiquitination remains unclear [Kawai T et al 2004]. It has been demonstrated that IRF7 is ubiquitinated by TRAF6 at multiple sites both in vitro and in vivo[Ning et al 2008].It has been also shown that K63-linked ubiquitination of IRF7 is independent of its C-terminal functional phosphorylation sites.
Literature References
PubMed ID Title Journal Year
18710948 TRAF6 and the three C-terminal lysine sites on IRF7 are required for its ubiquitination-mediated activation by the tumor necrosis factor receptor family member latent membrane protein 1

Bentz, GL, Ning, S, Pagano, JS, Darnay, BG, Campos, AD

Mol Cell Biol 2008
15361868 Interferon-alpha induction through Toll-like receptors involves a direct interaction of IRF7 with MyD88 and TRAF6

Kawai, T, Takeuchi, O, Inoue, J, Matsuda, M, Terai, K, Ishii, KJ, Sato, S, Yamamoto, M, Akira, S, Uematsu, S, Coban, C, Hemmi, H

Nat Immunol 2004
Catalyst Activity

ubiquitin-protein transferase activity of IRF7:TRAF6:p-3S,3T-IRAK1:p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 [endosome membrane]

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